Three-dimensional bio-printing of decellularized extracellular matrix-based bio-inks for cartilage regeneration:a systematic review  

作　　者：Melika Sahranavard Soulmaz Sarkari SeyedehMina Safavi Farnaz Ghorbani 

机构地区：[1]Biomaterials Research Group,Department of Nanotechnology and Advanced Materials,Materials and Energy Research Center,Tehran,Iran [2]Department of Biomedical Engineering,Science and Research Branch,Islamic Azad University,Tehran,Iran [3]Institute of Biomaterials,Department of Materials Science and Engineering,University of Erlangen-Nuremberg,Erlangen,Germany.

出　　处：《Biomaterials Translational》2022年第2期105-115,共11页生物材料转化电子杂志（英文）

基　　金：The work was supperted by the Alexander von Humboldt foundation(to FG).

摘　　要：Cartilage injuries are common problems that increase with the population aging.Cartilage is an avascular tissue with a relatively low level of cellular mitotic activity,which makes it impossible to heal spontaneously.To compensate for this problem,three-dimensional bio-printing has attracted a great deal of attention in cartilage tissue engineering.This emerging technology aims to create three-dimensional functional scaffolds by accurately depositing layer-by-layer bio-inks composed of biomaterial and cells.As a novel bio-ink,a decellularized extracellular matrix can serve as an appropriate substrate that contains all the necessary biological cues for cellular interactions.Here,this review is intended to provide an overview of decellularized extracellular matrix-based bio-inks and their properties,sources,and preparation process.Following this,decellularized extracellular matrix-based bio-inks for cartilage tissue engineering are discussed,emphasizing cell behavior and in-vivo applications.Afterward,the current challenges and future outlook will be discussed to determine the conclusing remarks.

关 键 词：3D bio-printing CARTILAGE DECELLULARIZATION dECM tissue engineering 

分 类 号：R31[医药卫生—基础医学]