利用加权基因共表达网络分析小细胞肺癌枢纽基因  

Analysis of hub genes in small-cell lung carcinoma by weighted gene co-expression network

作　　者：邢永华[1] 宋培培 苏占海 王海燕[1] 刘燕[1] 安娟 郭映花[1] XING Yonghua;SONG Peipei;SU Zhanhai;WANG Haiyan;LIU Yan;AN Juan;GUO Yinghua(Department of Medicine,Qinghai University,Antitumor Research Team of Chinese and Tibetan Medicine,Xining 810016,China;Global Health Institute,Bureau of International Health Cooperation,National Center for Global Health and Medicine,Japan)

机构地区：[1]青海大学医学部,中藏药抗肿瘤科研团队,青海西宁810016 [2]全球健康研究所,国际医疗协力局,日本国立国际医疗研究中心,日本

出　　处：《中国高原医学与生物学杂志》2022年第3期184-199,共16页Journal of Chinese High Altitude Medicine & Biology

基　　金：supported by The “Chunhui” Plan Project(z2016088)of the Ministry of Education and The Youthful Scientific Research Found Team Building Project of Medical College of Qinghai University(2015-KT-1)。

摘　　要：目的 初步筛选小细胞肺癌(Small-cell lung carcinoma, SCLC)的枢纽基因,为多靶标治疗提供线索。方法 利用加权基因共表达网络技术分析SCLC基因表达谱特征及相关枢纽基因。结果 确定了7 844个差异基因,8个基因模块与SCLC的发生、发展相关。初步确定NLN、TMEM40、TOP2A、COL5A2、SNX1、NDUFA13、C14orf159、GIMAP4等8个基因为SCLC发生的枢纽基因。结论 确定的8个枢纽基因或将成为有价值的诊断与治疗靶标。Objective The hub genes of Small-cell lung carcinoma(SCLC)were preliminarily screened to provide clues for multi-target therapy.Methods The characteristics of SCLC gene expression profile and related hub genes were analyzed by weighted gene co-expression network.Results A total of 7 844 differential genes were identified, and 8 gene modules were related to the occurrence and development of SCLC.NLN,TMEM40,TOP2A,COL5A2,SNX1,NDUFA13,C14orf159 and GIMAP4 were identified as the hub genes of SCLC.Conclusions The eight hub genes identified in the paper may be valuable diagnostic and therapeutic targets.

关 键 词：肺癌 基因 表达 网络 分析 模块 枢纽 

分 类 号：R734.2[医药卫生—肿瘤]