Correlation of periodontal diseases with intracranial aneurysm formation:novel predictive indicators  

作　　者：Keyun Liu Jia Sun Lingling Shao Hongwei He Qinglin Liu Youxiang Li Huijian Ge 

机构地区：[1]Department of Interventional Neuroradiology,Beijing Neurosurgical Institute and Beijing Tiantan Hospital,Capital Medical University,No.119,West Road of South Fourth Ring,Fengtai,Beijing 100070,People’s Republic of China [2]Department of Stomatology,Tianjin Stomatological Hospital,Hospital of Stomatology,Nankai University,Tianjin 300041,People’s Republic of China [3]Department of Tuberculosis,Beijing Tuberculosis and Thoracic Tumor Institute,Beijing Chest Hospital,Capital Medical University,Beijing 101149,People’s Republic of China

出　　处：《Chinese Neurosurgical Journal》2021年第3期165-170,共6页中华神经外科杂志（英文）

基　　金：This study was supported by the National Natural Science Foundation(81471166);Capital Medical Development Research Foundation of China(2016-1-1075).

摘　　要：Background:We investigated whether periodontal diseases,specifically,periodontitis and gingivitis,could be risk factors of the incidence of intracranial aneurysms(IAs).Methods:We performed a case–control study to compare the differences in the periodontal disease parameters of 281 cases that were divided into the IAs group and non-IAs group.All cases underwent complete radiographic examination for IAs and examination for periodontal health.Results:Comparing with those in the non-IAs group,the cases in the IAs group were older(53.95±8.56 vs 47.79±12.33,p<0.001)and had a higher incidence of hypertension(76 vs 34,p=0.006).Univariate logistic regression analysis revealed that age(>50 years)and hypertension were predictive risk factors of aneurysm formation(odds ratio[OR]1.047,95%confidence interval[95%CI]1.022–1.073,p<0.001 and OR 2.047,95%CI 1.232–3.401,p=0.006).In addition,univariate and multivariate logistic regression analyses showed that the parameters of periodontal diseases,including gingival index,plaque index,clinical attachment loss,and alveolar bone loss,were significantly associated with the occurrence of IAs(all p<0.05).For further statistical investigation,the parameters of periodontal diseases were divided into four layers based on the quartered data.Poorer periodontal health condition(especially gingival index>1.1 and plaque index>1.5)had the correlation with IAs formation(p=0.007 and p<0.001).Conclusion:Severe gingivitis or periodontitis,combining with hypertension,is significantly associated with the incidence of IAs.

关 键 词：GINGIVITIS Intracranial aneurysms INFLAMMATION PERIODONTITIS 

分 类 号：R781.4[医药卫生—口腔医学] R743[医药卫生—临床医学]