Physicochemical degradation of phycocyanin and means to improve its stability:A short review  

作　　者：Aïda Adjali Igor Clarot Zilin Chen Eric Marchioni Ariane Boudier 

机构地区：[1]Universite de Lorraine,CITHEFOR,F-54000,Nancy,France [2]Key Laboratory of Combinatorial Biosynthesis and Drug Discovery,Ministry of Education,Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals,and Wuhan University School of Pharmaceutical Sciences,Wuhan,430071,China [3]State Key Laboratory of Transducer Technology,Chinese Academy of Sciences,Beijing,100080,China [4]Universite de Strasbourg,CNRS,IPHC UMR 7178,F-67000,Strasbourg,France

出　　处：《Journal of Pharmaceutical Analysis》2022年第3期406-414,共9页药物分析学报（英文版）

摘　　要：The cyanobacterium Arthrospira platensis,spirulina,is a source of pigments such as phycobiliprotein and phycocyanin.Phycocyanin is used in the food,cosmetics,and pharmaceutical industries because of its antioxidant,anti-inflammatory,and anticancer properties.The different steps involved in extraction and purification of this protein can alter the final properties.In this review,the stability of phycocyanin(pH,temperature,and light)is discussed,considering the physicochemical parameters of kinetic modeling.The optimal working pH range for phycocyanin is between 5.5 and 6.0 and it remains stable up to 45℃;however,exposure to relatively high temperatures or acidic pH decreases its half-life and increases the degradation kinetic constant.Phycobiliproteins are sensitive to light;preservatives such as mono-and disaccharides,citric acid,or sodium chloride appear to be effective stabilizing agents.Encapsulation within nano-or micro-structured materials such as nanofibers,microparticles,or nanoparticles,can also preserve or enhance its stability.

关 键 词：Arthrospira platensis SPIRULINA Phycocyanin stability PRESERVATIVES ENCAPSULATION 

分 类 号：R917[医药卫生—药物分析学]