Multiple roles for cholinergic signaling in pancreatic diseases  

作　　者：Jun-Min Yang Xiao-Yu Yang Jian-Hua Wan 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China

出　　处：《World Journal of Gastroenterology》2022年第25期2910-2919,共10页世界胃肠病学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China,No.82100686.

摘　　要：Cholinergic nerves are widely distributed throughout the human body and participate in various physiological activities,including sensory,motor,and visceral activities,through cholinergic signaling.Cholinergic signaling plays an important role in pancreatic exocrine secretion.A large number of studies have found that cholinergic signaling overstimulates pancreatic acinar cells through muscarinic receptors,participates in the onset of pancreatic diseases such as acute pancreatitis and chronic pancreatitis,and can also inhibit the progression of pancreatic cancer.However,cholinergic signaling plays a role in reducing pain and inflammation through nicotinic receptors,but enhances the proliferation and invasion of pancreatic tumor cells.This review focuses on the progression of cholinergic signaling and pancreatic diseases in recent years and reveals the role of cholinergic signaling in pancreatic diseases.

关 键 词：ACETYLCHOLINE Muscarinic receptors Nicotinic receptors Pancreatic exocrine PANCREATITIS Pancreatic cancer 

分 类 号：R576[医药卫生—消化系统]