Immunoadsorption therapy for Klinefelter syndrome with antiphospholipid syndrome in a patient:A case report  

作　　者：You Song Yong-Zhen Xiao Cheng Wang Rong Du 

机构地区：[1]Department of Rheumatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China [2]Health Management Center,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China

出　　处：《World Journal of Clinical Cases》2022年第19期6580-6586,共7页世界临床病例杂志

摘　　要：BACKGROUND Klinefelter syndrome(KS) is a genetic disease of male sex chromosome malformations that affects sperm production and reduces testosterone production. It has been reported that there is currently more than 10 cases of KS combined with antiphospholipid syndrome(APS).CASE SUMMARY Here, we describe a 31-year-old male patient with chromosome 47, XXY type, who suffered deep vein thrombosis of the lower limbs accompanied by abnormal antiphospholipid antibody, lupus anticoagulant and factor VⅢ. After treatment with immunoadsorption therapy, glucocorticoids, cyclophosphamide, intravenous immunoglobulin and anticoagulant therapy, the patient showed dramatic symptomatic improvement. During the follow-up, the patient did not develop any new thrombotic events.CONCLUSION Immunoadsorption combined with glucocorticoid and cyclophosphamide shock comprehensive treatment has achieved significant results for patients with KS combined with antiphospholipid syndrome.

关 键 词：Klinefelter syndrome Antiphospholipid syndrome IMMUNOADSORPTION GLUCOCORTICOID CYCLOPHOSPHAMIDE Bone morphogenetic protein receptor type-2 Case report 

分 类 号：R593.2[医药卫生—内科学] R596.1[医药卫生—临床医学]