Adipocytokine profile in children with Kawasaki disease at a mean follow-up period of 5.5 years: A study from North India  

作　　者：Dibya Lochan Praharaj Amit Rawat Anju Gupta Kanika Arora Rakesh Kumar Pilania Sagar Bhattad Surjit Singh 

机构地区：[1]Pediatric Allergy and Immunology Unit,Advanced Pediatrics Centre,Post Graduate Institute of Medical Education and Research,Chandigarh 160012,India

出　　处：《World Journal of Clinical Pediatrics》2022年第4期360-368,共9页世界临床儿科杂志

摘　　要：BACKGROUND Kawasaki disease(KD)is an acute self-limited vasculitis with a predilection for coronary arteries.Children with KD may have altered lipid metabolism and abnormal lipid profiles that may last for prolonged periods.However,there is a paucity of literature on the role of adipocytokines in KD.AIM To estimate the levels of adipocytokines(adiponectin,leptin and resistin)during the convalescent phase of KD.METHODS Twenty children,who had KD at least three years earlier,were enrolled in this study.In addition,20 healthy controls were also enrolled.Clinical and laboratory profiles of patients were obtained from hospital records.Serum adiponectin,leptin and resistin levels were estimated by enzyme-linked immunosorbent assay.RESULTS Mean age of the patients in the study group was 10.15±3 years and the male:female ratio was 1.5:1.Median serum resistin levels in patients with KD(27.77 ng/mL;[IQR:18.66,48.90])were decreased compared to controls(21.20 ng/mL;[IQR:14.80,27.00])(P=0.04).Median serum leptin levels in cases and controls were 1.83 ng/mL;(IQR:1.13,3.80),and 1.10 ng/mL;(IQR:0.41,2.88),respectively(P=0.09).Median serum adiponectin levels were similar in both cases(12.20μg/mL;[IQR:9.76,17.97])and controls(13.95μg/mL;[IQR:11.17,22.58]);(P=0.18).There was no significant difference in all 3 adipocytokines between children with(4/20)and without coronary artery abnormalities(16/20).CONCLUSION Serum resistin levels were significantly elevated in patients with KD during the convalescent phase compared to controls.Serum leptin levels appeared to be higher in patients with KD,although the difference was not statistically significant.Adiponectin levels were similar in both cases and controls.Raised resistin and leptin levels may partially explain lipid perturbations observed during the convalescent phase of KD.

关 键 词：ADIPOCYTOKINES ADIPONECTIN RESISTIN LEPTIN Lipid metabolism Kawasaki disease Convalescent phase 

分 类 号：R725.4[医药卫生—儿科]