Pancreatic involvement in celiac disease  

作　　者：Daniel Vasile Balaban Iulia Enache Marina Ciochina Alina Popp Mariana Jinga 

机构地区：[1]Department of Internal Medicine and Gastroenterology,Carol Davila University of Medicine and Pharmacy,Bucharest 020021,Romania [2]Dr.Carol Davila Central Military Emergency University Hospital,Bucharest 020021,Romania [3]Department of Pediatrics,Carol Davila University of Medicine and Pharmacy,Bucharest 020021,Romania [4]National Institute for Mother and Child Health,Bucharest 020021,Romania

出　　处：《World Journal of Gastroenterology》2022年第24期2680-2688,共9页世界胃肠病学杂志（英文版）

摘　　要：Celiac disease(CD)is well recognized as a systemic,chronic autoimmune disease mainly characterized by gluten-sensitive enteropathy in genetically predisposed individuals but with various extraintestinal features.One of the affected organs in CD is the pancreas,consisting of both endocrine and exocrine alterations.Over the last decades there has been increasing interest in the pancreatic changes in CD,and this has been reflected by a great number of publications looking at this extraintestinal involvement during the course of CD.While pancreatic endocrine changes in CD,focusing on type 1 diabetes mellitus,are well documented in the literature,the relationship with the exocrine pancreas has been less studied.This review summarizes currently available evidence with regard to pancreatic exocrine alterations in CD,focusing on risk of pancreatitis in CD patients,association with autoimmune pancreatitis,prevalence and outcomes of pancreatic exocrine insufficiency in newly diagnosed and gluten-free diet treated CD patients,and the link with cystic fibrosis.In addition,we discuss mechanisms behind the associated pancreatic exocrine impairment in CD and highlight the recommendations for clinical practice.

关 键 词：PANCREAS Celiac disease AUTOIMMUNE PANCREATITIS Cystic fibrosis Exocrine insufficiency 

分 类 号：R576[医药卫生—消化系统]