Current progress and emerging technologies for generating extrapancreatic functional insulin-producing cells  

作　　者：Md Aejaz Habeeb Sandeep Kumar Vishwakarma Safwaan Habeeb Aleem Ahmed Khan 

机构地区：[1]Centre for Liver Research and Diagnostics,Deccan College of Medical Sciences,Hyderabad 500058,Telangana,India

出　　处：《World Journal of Translational Medicine》2022年第1期1-13,共13页世界转化医学杂志

摘　　要：Diabetes has been one of the major concerns in recent years,due to the increasing rate of morbidity and mortality worldwide.The available treatment strategies for uncontrolled diabetes mellitus(DM)are pancreas or islet transplantation.However,these strategies are limited due to unavailability of quality pancreas/islet donors,life-long need of immunosuppression,and associated complications.Cell therapy has emerged as a promising alternative options to achieve the clinical benefits in the management of uncontrolled DM.Since the last few years,various sources of cells have been used to convert into insulin-producingβ-like cells.These extrapancreatic sources of cells may play a significant role inβ-cell turnover and insulin secretion in response to environmental stimuli.Stem/progenitor cells from liver have been proposed as an alternative choice that respond well to glucose stimuli under strong transcriptional control.The liver is one of the largest organs in the human body and has a common endodermal origin with pancreatic lineages.Hence,liver has been proposed as a source of a large number of insulinproducing cells.The merging of nanotechnology and 3D tissue bioengineering has opened a new direction for producing islet-like cells suitable for in vivo transplantation in a cordial microenvironment.This review summarizes extrapancreatic sources for insulin-secreting cells with reference to emerging technologies to fulfill the future clinical need.

关 键 词：Diabetes mellitus Cell-based therapy Insulin producing cells Extrapancreatic sources BIOMATERIALS Tissue engineering 

分 类 号：R73[医药卫生—肿瘤]