肠道微生态在结直肠癌预防和治疗中的研究进展  

Research progress of gut microbiota in the prevention and treatment of colorectal cancer

作　　者：兰平[1] 殷盛梅 何真[1] Lan Ping;Yin Shengmei;He Zhen(Department of Colorectal Surgery,the Six Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China;School of Medicine,Sun Yat-sen University,Shenzhen 518107,Guangdong Province,China)

机构地区：[1]中山大学附属第六医院结直肠外科,广州510655 [2]中山大学医学院,深圳518107

出　　处：《中华消化外科杂志》2022年第6期730-736,共7页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金(81970452,81902938);广东省自然科学基金(2020A1515011248);深圳市科技计划项目(JCYJ20190807161807867)。

摘　　要：结直肠癌是常见的消化道恶性肿瘤,其发生发展与肠道微生态密切相关。肠道菌群主要通过释放毒素、产生代谢物等,改变宿主肠道免疫环境,影响肠道屏障功能,参与结直肠癌的发生发展。肠道菌群可以作为生物标志物,用于结直肠癌的早期筛查、预测预后等。此外,肠道菌群还可以影响结直肠癌的化疗、放疗及免疫治疗效果。笔者就肠道微生态在结直肠癌的发生发展、筛查、预后预测及治疗中的作用进行评述,探讨其在结直肠癌预防和治疗中的应用前景。Colorectal cancer is a common malignancy of the digestive tract,and the gut microbiota is closely related to the occurrence and development of colorectal cancer.The intestinal florae mainly change the host intestinal immune environment and affect the function of the intes-tinal barrier by releasing toxins and producing metabolites to participate the occurrence and deve-lopment of colon cancer.The intestinal florae can be used as biomarkers for early screening and prognosis prediction for colorectal cancer.In addition,the intestinal florae can affect the efficacy of chemotherapy,radiotherapy and immunotherapy for colorectal cancer.The authors review the research progress of gut microbiota in occurrence and development,screening,prognosis prediction and treatment of colorectal cancer,and discuss the application prospects of gut microbiota in the prevention and treatment of colorectal cancer.

关 键 词：肠道屏障功能 早期筛查 肠道微生态 消化道恶性肿瘤 结直肠癌 肠道菌群 免疫治疗 肠道免疫 

分 类 号：R735.34[医药卫生—肿瘤]