Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy  

作　　者：Hiroshi Hongo Takeo Kosaka Hideyuki Hayashi Kohei Nakamura Hiroshi Nishihara Shuji Mikami Himisha Beltran Mototsugu Oya 

机构地区：[1]Department of Urology,Keio University School of Medicine,35 Shinanomachi,Shinjuku-ku,Tokyo 160-8582,Japan [2]Genomics Unit,Keio Cancer Center,Keio University School of Medicine,35 Shinanomachi,Shinjuku-ku,Tokyo 160-8582,Japan [3]Division of Diagnostic Pathology,Keio University Hospital,35 Shinanomachi,Shinjuku-ku,Tokyo 160-8582,Japan [4]Department of Medical Oncology,Dana-Farber Cancer Institute,450 Brookline Avenue,Boston,MA 02215,USA

出　　处：《Asian Journal of Andrology》2022年第1期116-118,共3页亚洲男性学杂志（英文版）

基　　金：Yoko Suzuki provided technical assistance.This study was supported in part by Grants-in-Aid for Scientific Research(#17K16813 to H Hongo and#17K11158 and#20H03817 to TK)from the Ministry of Education,Culture,Sports,Science,and Technology of Japan;The study was supported in part by research Grant to TK from the Takeda Science Foundation,Japan。

摘　　要：Dear Editor,Spinal and bulbar muscular atrophy(SBMA)or Kennedy’s disease is a rare X-linked,recessive,lower motor neuron disease caused by a CAG repeat expansion within the first exon of the androgen receptor(AR)gene.Instability of the CAG-triplet repeat impacts AR function;therefore,men with SBMA are thought to be at a very low risk of prostate cancer.We previously reported a case of high-risk prostate cancer with SBMA(repeat length 46).

关 键 词：ATROPHY MUSCULAR cancer 

分 类 号：R737.25[医药卫生—肿瘤]