记忆任务指标评估抑郁障碍风险研究  

Performance of memory task indicators for assessment of the risk of depressive disorders

作　　者：余鸽[1] 娄乐 徐方忠[1,2] YU Ge;LOU Le;XU Fangzhong(Department of Clinical Psychology,Tongde Hospital of Zhejiang Province,Hangzhou,Zhejiang 310012,China;Zhejiang Sci-Tech University,Hangzhou,Zhejiang 310018,China)

机构地区：[1]浙江省立同德医院临床心理科,浙江杭州310012 [2]浙江理工大学,浙江杭州310018

出　　处：《预防医学》2022年第7期687-691,共5页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：浙江省软科学研究计划(2021C35114);浙江省卫生厅科教处项目(2022KY710)。

摘　　要：目的应用经典心理学记忆任务测试指标评估抑郁障碍风险,为抑郁障碍临床评估提供依据。方法选择2021年1—9月在某三甲医院精神科和临床心理科治疗的抑郁障碍患者68例纳入病例组,选择该院职工、社会志愿者、在校学生31人纳入对照组;采用经典心理学记忆任务测试,包括内隐记忆、短时记忆和工作记忆,比较两组研究对象的错误率和反应时;采用多因素logistic回归模型和受试者工作特征(ROC)曲线筛选抑郁障碍预测指标。结果病例组男性29例,女性39例,年龄为(24.12±7.40)岁,大专以上文化程度46例。对照组男性15人,女性16人,年龄为(26.45±6.65)岁,大专以上文化程度23人。多因素logistic回归分析结果显示,年龄>18岁(OR=3.431,95%CI:1.259~9.350)、2-back错误率(OR=1.056,95%CI:1.016~1.097)和短时记忆错误率(OR=1.078,95%CI:1.009~1.152)与抑郁障碍有统计学关联。ROC曲线分析结果显示,2-back错误率预测抑郁障碍风险的曲线下面积(AUC)值为0.730(95%CI:0.630~0.831),临界值为22.5%,灵敏度为42.6%,特异度为93.5%;短时记忆错误率预测抑郁障碍风险的AUC值为0.717(95%CI:0.605~0.829),临界值为23.5%,灵敏度为67.6%,特异度为71.0%;两者联合预测抑郁障碍风险的AUC值为0.829(95%CI:0.734~0.923),灵敏度为75.0%,特异度为80.6%。结论短时记忆和工作记忆指标可用于评估抑郁障碍风险。Objective To evaluate the risk of depressive disorders using memory task indicators,so as to provide in⁃sights into clinical assessment of depressive disorders.Methods A total of 68 patients with depressive disorders under⁃going treatments in the departments of psychiatrics and clinical psychology in a tertiary hospital during the period from January to September,2021 were enrolled as the case group,while a total of 31 hospital employees,social volunteers and university students served as controls.The error rate and response time of classical memory task experiments were compared between the two groups,including implicit memory,short-term memory and working memory tasks.In addi⁃tion,the predictive indicators of depressive disorders were identified using multivariable logistic regression analysis and receiver operative characteristics(ROC)curve.Results The case group included 29 men and 39 women and had a mean age of(24.12±7.40)years,including 46 subjects with an educational level higher than diploma.The control group included 15 men and 16 women and had a mean age of(26.45±6.65)years,including 23 subjects with an educational level higher than diploma.Multivariable logistic regression analysis showed significant associations of age of>18 years(OR=3.431,95%CI:1.259-9.350),error rate of 2-back task(OR=1.056,95%CI:1.016-1.097)and error rate of shortterm memory tasks(OR=1.078,95%CI:1.009-1.152)with the development of depressive disorders.ROC curve analysis showed that the error rate of 2-back tasks showed an area under the ROC curve(AUC)of 0.730(95%CI:0.630-0.831),cutoff of 22.5%,sensitivity of 42.6%and specificity of 93.5%for prediction of the risk of depressive disorders,and the error rate of short-term memory tasks showed an AUC of 0.717(95%CI:0.605-0.829),cutoff of 23.5%,sensitiv⁃ity of 67.6%and specificity of 71.0%for prediction of the risk of depressive disorders.In addition,the combination of the error rate of 2-back tasks and the error rate of short-term memory tasks showed an AUC of 0.829(95%CI:0.73

关 键 词：抑郁障碍 内隐记忆 短时记忆 工作记忆 风险预测 

分 类 号：R749.4[医药卫生—神经病学与精神病学]