DMD 的肌膜损伤机制及其修复治疗的研究进展  

Research progress on the mechanism of sarcolemma damage and repair treatment of Duchenne muscular dystrophy

作　　者：赵治鹏 李善刚 ZHAO Zhipeng;LI Shangang(Institute of Primate Translational Medicine,Kunming University of Science and Technology,Kunming 650500,China;State Key Laboratory of Primate Biomedical Research,Kunming 650500)

机构地区：[1]昆明理工大学灵长类转化医学研究院,昆明650500 [2]省部共建非人灵长类生物医学国家重点实验室,昆明650500

出　　处：《中国比较医学杂志》2022年第6期93-99,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(81930121)。

摘　　要：杜氏肌营养不良症(Duchenne muscular dystrophy,DMD)是一种严重的致死性肌肉疾病,定位于肌膜的抗肌萎缩蛋白dystrophin功能缺失是其致病因素。目前DMD研究的热点聚焦于如何对疾病进行治疗,其中膜功能的恢复已经成为临床治疗的密切关注点。本综述将着重总结dystrophin异常引起肌膜损伤的机制及膜修复治疗的研究进展,通过从肌膜的角度理解DMD的病理机制来促进干预治疗的研究进程。Duchenne muscular dystrophy(DMD)is a fatal muscle disease caused by the loss of dystrophin protein,which is localized in the sarcolemma.Currently,DMD research concentrates on how to treat the disease,and the restoration of membrane function has become a promising therapeutic approach.This review focuses on the mechanism by which muscle membrane damage is caused by dystrophin abnormality and summarizes the research progress regarding membrane repair therapy toward its clinical application.

关 键 词：杜氏肌营养不良症 肌膜损伤 肌膜修复治疗 

分 类 号：R-33[医药卫生]