膳食乳化剂对结直肠癌影响的研究进展  

Research progress on the effect of dietary emulsifiers on colorectal cancer

作　　者：王晨曦[1] 王秀宏[1] WANG Chenxi;WANG Xiuhong(Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学,哈尔滨150081

出　　处：《中国比较医学杂志》2022年第6期111-116,共6页Chinese Journal of Comparative Medicine

基　　金：国家自然青年科学基金项目(81703232)。

摘　　要：结直肠癌(colorectal cancer,CRC)是世界上最常见的诊断癌症之一,已成为癌症相关死亡的主要原因。最近的研究显示,广泛使用的食品添加剂———膳食乳化剂羧甲基纤维素钠(carboxymethylcellulose,CMC)和聚山梨酯80(polysorbate 80,P80)能影响肠道菌群,改变肠道菌群代谢产物及促进结肠炎症。而且目前对CRC的研究显示,CRC的发生发展与肠道菌群、肠道菌群代谢产物、炎症等密切相关。故本综述将主要围绕这些影响因素去探讨膳食乳化剂CMC和P80促进CRC发生发展的可能性,为研究CMC和P80对CRC发生发展的影响提供参考。Colorectal cancer(CRC)is one of the most commonly diagnosed cancers in the world,and it has become the leading cause of cancer-related deaths.Recent studies have shown that the dietary emulsifiers carboxymethylcellulose(CMC)and polysorbate 80(P80),which are widely used food additives,can affect the gut microbiota,change the metabolites of intestinal flora,and promote colon inflammation.The current research on CRC indicates that the occurrence and development of CRC are closely related to gut microbiota,intestinal flora metabolites,and inflammation.Therefore,this review focuses on these influencing factors to explore the possibility of whether dietary emulsifiers CMC and P80 promote the occurrence and development of CRC,and it provide references for studying the influences of CMC and P80 on the occurrence and development of CRC.

关 键 词：羧甲基纤维素钠 聚山梨酯80 肠道菌群 炎症 结直肠癌 

分 类 号：R-33[医药卫生]