Long-term adjuvant administration of temozolomide impacts serum ions concentration in high-grade glioma  

作　　者：Liyun Zhong Pei Yang Chuanbao Zhang Zheng Wang Tao Jiang Baoshi Chen Xia Shan Xiaoguang Qiu 

机构地区：[1]Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing,China [2]Department of Molecular Neuropathology,Beijing Neurosurgical Institute,Capital Medical University,Beijing,China [3]Chinese Glioma Genome Atlas Network(CGGA)and Asian Glioma Genome Atlas Network(AGGA),Beijing,China [4]Center of Brain Tumor,Beijing Institute for Brain Disorders,Beijing,China [5]China National Clinical Research Center for Neurological Diseases,119 South 4th Ring Road West,Beijing 100070,China [6]Department of Radiotherapy,Beijing Tiantan Hospital,Capital Medical University,119 South 4th Ring Road West,Beijing 100070,China

出　　处：《Chinese Neurosurgical Journal》2022年第2期111-119,共9页中华神经外科杂志（英文）

基　　金：This work was supported by funding from the National Key Research and Development Plan(No. 2016YFC0902500);the National Natural Science Foundation of China(No. 81903060);the Cultivation Plan of Beijing Hospital Management Center(PX2021025)

摘　　要：Background:Adjuvant temozolomide(TMZ)chemotherapy with standard regimen remarkably improves survival in patients with high-grade glioma(HGG).However,the influence of long-term TMZ chemotherapy on serum ions concentration is unclear.Methods:One hundred and thirty-eight patients with HGG were included.Their blood samples were collected for blood biochemistry and routine test.The alteration in serum ions concentration,total protein,albumin,globin,and blood cells counts were used to identify the impact of long-term TMZ chemotherapy.Results:Through the comparation of quantitative value of diverse parameters among different chemotherapy cycles,we identified that serum potassium concentration had a downward trend after TMZ administration(1st vs.6th,p<0.001;1st vs.12th,p<0.001).Additionally,the correlation analysis showed that platelets was negatively correlated with chemotherapy cycles(r=−0.649,p=0.023).The hematological adverse events mainly centered on grade 1 to 2.Conclusion:Long-term administration of TMZ may lead to serum ions disturbance.Besides the myelosuppression,we should pay attention to the alteration in serum ions concentration,and give patients proper symptomatic treatment when necessary.

关 键 词：High-grade glioma(HGG) Temozolomide(TMZ) CHEMOTHERAPY TOXICITY 

分 类 号：R739.4[医药卫生—肿瘤]