Localizing epileptic focus and assessing electrical stimulus effects on epilepsy in rats using stretchable micro electrocorticogram electrodes  

利用可拉伸微脑皮层电极定位癫痫病灶并评估电刺激对大鼠癫痫发作的影响

作　　者：Qi Zhang Yang Zhao Lin Wang Mingyi Wei Mei Yu Jianping Huang Guanglin Li Renheng Wang Shiwei Du Zhiyuan Liu 张琪;赵阳;王琳;魏明怡;于玫;黄剑平;李光林;王任衡;杜世伟;刘志远(College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen 518060,China;CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems,Neural Engineering Center,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;Neurosurgery Department,Shenzhen University General Hospital,Shenzhen 518055,China)

机构地区：[1]College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen 518060,China [2]CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems,Neural Engineering Center,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [3]Neurosurgery Department,Shenzhen University General Hospital,Shenzhen 518055,China

出　　处：《Science China Materials》2022年第8期2244-2251,共8页中国科学（材料科学（英文版）

基　　金：financially supported by the National Key Scientific Research Instrument Development Project(81927804);the Major Scientific and Technological Innovation Projects of Shandong Province(2019JZZY011112);the Clinical Research Project of Shandong University(2020SDUCRCB004);the National Nature Science Foundation of China(81960419 and 81760416)。

摘　　要：Epilepsy is a chronic nervous disease with increasing incidence worldwide,while the accurate localization of epileptic focus and the corresponding treatment are still challenging due to the lack of effective tools to monitor and modulate the related brain neurological activities.In this work,stretchable micro electrocorticogram(mECoG)electrodes are developed and used to investigate penicillininduced epilepsy in rats.The electrodes possess excellent stretchability,conformality,anti-interference ability and sufficient resolution to successfully monitor electroencephalogram(EEG)signals,which is superior to traditional rigid polyimide-based electrodes.Characteristic epileptic spike waves are detected and analyzed to study the epileptic focus and electrical stimulus effects during epileptic seizures.It is found that the spike waves occur first in the visual cortex which is likely to be the epileptic focus.Epileptic spike wave frequency quickly increases to 1.07 Hz where it reaches a plateau and remains stable.There is no dominant brain hemisphere that would show early warning of epileptic seizures.Electrical stimuli for various times are applied after administering penicillin.It is found that 15 min of electrical stimulus has the best restraining effect on epileptic seizures.The mECoG electrodes developed in this study show potentials for applications in stretchable biomedical devices.癫痫是一种慢性神经系统疾病,其发病率在全球范围内不断上升,但由于缺乏有效的工具来监测和调节相关的脑神经活动,癫痫病灶的准确定位和相应的治疗仍然具有挑战性.在这项工作中,我们开发了可拉伸微脑皮层(mECoG)电极,并用于研究青霉素诱导的大鼠癫痫发作.该电极具有良好的延展性、共形性、抗干扰能力和高分辨率,能够成功地监测脑电信号,并优于传统的刚性聚酰亚胺电极.通过检测和分析特征性癫痫棘波,我们研究了癫痫发作期间的癫痫灶和电刺激效应.研究发现,棘波首先出现在视皮层,很可能是癫痫的病灶.癫痫发作后棘波频率迅速增加至1.07 Hz,达到平台并保持稳定.没有一个大脑半球可以显示癫痫发作的早期预警.青霉素诱导后,我们施加了不同时长的电刺激.研究发现,15分钟的电刺激对癫痫发作的抑制效果最好.本研究开发的mECoG电极在可拉伸生物医学器件中具有应用前景.

关 键 词：stretchable electrode stretchable electronics ELECTROCORTICOGRAM EPILEPSY electrical stimulus 

分 类 号：R742.1[医药卫生—神经病学与精神病学]