A BODIPY-modified polymeric micelle for sustaining enhanced photodynamic therapy  

作　　者：Yun-Chang Zhang Lan She Zi-Yue Xu Ze-Kun Wang Zhiqiang Ma Feng Yang Zhan-Ting Li 

机构地区：[1]Department of Inorganic Chemistry,School of Pharmacy,Naval Medical University,Shanghai 200433,China [2]Department of Chemistry,Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials,Fudan University,Shanghai 200438,China

出　　处：《Chinese Chemical Letters》2022年第6期3277-3280,共4页中国化学快报（英文版）

基　　金：Shanghai Sailing Program (No. 20YF1458000)。

摘　　要：Photodynamic therapy(PDT) has been gaining popularity in both scientific research and clinic applications due to its non-invasiveness and spatiotemporal targeting properties. Nevertheless, the local hypoxic microenvironment in tumor tissue impedes PDT universality. To overcome this drawback, a 2-pyridonebearing BODIPY photosensitizer was synthesized rationally and introduced to polyethyleneglycol-bpoly(aspartic acid) to form a photosensitizer-^(1)O_(2) generation, storage/release agent dual-loading system(PEG-b-PAsp-BODIPY). The investigation of the PDT effect at different illumination conditions in vitro and in vivo revealed that the system tremendously inhibited tumor proliferation, indicating that this new PEG-b-PAsp-BODIPY could act as a potentially effective photo therapeutic system for cancer therapeutics.

关 键 词：Photodynamic therapy Polymeric micelle BODIPY 2-Pyridone TUMOR 

分 类 号：TQ317[化学工程—高聚物工业] R730.5[医药卫生—肿瘤]