Novel pyroptosis-independent functions of gasdermins  

作　　者：Ziran Qin Fangfang Zhou Long Zhang 

机构地区：[1]Zhejiang University City College,Hangzhou,China [2]Institutes of Biology and Medical Science,Soochow University,215123,Suzhou,China [3]MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network,Life Sciences Institute,Zhejiang University,310058,Hangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第5期1366-1368,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by a special program from the Ministry of Science and Technology of China(2021YFA101000);the Chinese National Natural Science Funds(U20A20393,U20A201376,31925013,3212500161,82041009,31871405,31701234,81902947,82041009,31671457,31571460,and 91753139);Jiangsu Provincial Distinguished Young Scholars award(BK20180043);the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003);A project Funded by the Priority Acadamic Program Development of Jiangsu Higher Education Institutions and the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX17_2036).

摘　　要：Recently,Rana et al.and Zhang et al.published two studies illustrating the important regulatory roles of gasdermin B(GSDMB)and-D(GSDMD)in inflammatory bowel disease(IBD)and intestinal immune homeostasis maintenance,respectively.1,2 Their findings collectively indicate that the gasdermins(GSDMs)can play a crucial role in restoring epithelial barrier function and shaping gut mucosal homeostasis.Moreover,neither of the functions of GSDMs revealed by these two studies are related to pyroptosis,which may provide new insights into the non-pyroptosis-dependent functions of GSDM proteins.

关 键 词：HOMEOSTASIS COLLECTIVE 

分 类 号：R574[医药卫生—消化系统]