PINK1-mediated Drp1^(S616) phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission  

作　　者：Qingtao Gao Runyi Tian Hailong Han Jesse Slone Caifang Wang Xiao Ke Tongmei Zhang Xiangyu Li Yuhong He Panlin Liao Fang Wang Ye Chen Shiqing Fu Kexuan Zhang Fangfang Zeng Yingxuan Yang Zhuo Li Jieqiong Tan Jiada Li Youming Lu Taosheng Huang Zhonghua Hu Zhuohua Zhang 

机构地区：[1]Institute of Molecular Precision Medicine,Xiangya Hospital,Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics,Hunan Key Laboratory of Medical Genetics,Central South University,Changsha,Hunan 410008,China [2]Department of Pediatrics,Jacobs School of Medicine and Biomedical Sciences,University at Buffalo,Buffalo,New York 14203,USA [3]Department of Physiology,School of Basic Medicine and Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [4]The Institute for Brain Research,Collaborative Innovation Center for Brain Science,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [5]Hunan Key Laboratory of Animal Models for Human Diseases,School of Life Sciences,Central South University,Changsha,Hunan 410008,China [6]Department of Neurosciences,University of South China Medical School,Hengyang,Hunan 421001,China [7]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [8]Department of Critical Care Medicine,Hunan Provincial Clinical Research Center for Critical Care Medicine,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第5期1719-1734,共16页信号转导与靶向治疗（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(31730036,81861138012,81161120498,81429002,31330031,82171506,and 31872778);the Discipline Innovative Engineering Plan(111 Program)of China(B13036);a key laboratory grant from Hunan province(2016TP1006);Science and Technology Major Project of Hunan Provincial Science and Technology Department(2018SK1030);the Department of Science and Technology of Hunan Province(grant 2021DK2001,and innovative team program 2019RS1010);The innovative team program from Department of Science&Technology of Hunan Province(2019RS1010);The innovation-driven team project from Central South University(2020CX016),and Hunan 100 Talents Program.

摘　　要：Dynamic change of mitochondrial morphology and distribution along neuronal branches are essential for neural circuitry formation and synaptic efficacy.However,the underlying mechanism remains elusive.We show here that Pink1 knockout(KO)mice display defective dendritic spine maturation,reduced axonal synaptic vesicles,abnormal synaptic connection,and attenuated long-term synaptic potentiation(LTP).Drp1 activation via ^(S616) phosphorylation rescues deficits of spine maturation in Pink1 KO neurons.

关 键 词：PLASTICITY ACTIVATION SYNAPTIC 

分 类 号：R338[医药卫生—人体生理学]