人工智能在结直肠癌数字化病理图像分析中的应用  

Application and Research Progress of Artificial Intelligence in Digital Pathological Image Analysis of Colorectal Cancer

作　　者：李晓燕 李晨[2] 陈灏源 张勇 张敬东 LI Xiaoyan;LI Chen;CHEN Haoyuan;ZHANG Yong;ZHANG Jingdong(Department of Pathology,Cancer Hospital of China Medical University,Liaoning Cancer Hospital and Institute,Shenyang 110042,China;College of Medicine and Biological Information Engineering,Northeastern University,Shenyang 110819,China;Department of Digestive Oncology,Cancer Hospital of China Medical University,Liaoning Cancer Hospital and Institute,Shenyang 110042,China)

机构地区：[1]中国医科大学肿瘤医院/辽宁省肿瘤医院病理科,沈阳110042 [2]东北大学医学与生物信息工程学院,沈阳110819 [3]中国医科大学肿瘤医院/辽宁省肿瘤医院消化内科,沈阳110042

出　　处：《协和医学杂志》2022年第4期542-548,共7页Medical Journal of Peking Union Medical College Hospital

基　　金：北京协和医学基金会瞳行病理公益项目。

摘　　要：计算机人工智能技术在数字病理中应用广泛、发展迅速,是肿瘤精准诊疗时代的一个里程碑。传统病理学作为肿瘤诊断的金标准具有高度主观性及不可重复性,且工作繁琐。基于人工智能技术对数字病理图像进行特征提取及定量分析,并转变为高保真、高通量的可挖掘/分析的数据,在肿瘤早期诊断、分级及构建预后模型等方面表现出独特优势。数字病理人工智能的发展为病理学科带来了难得的机遇,也是精准诊疗的未来发展趋势。本文概述人工智能在结直肠癌数字化病理图像分析中的应用现状和潜在价值,以期为临床诊疗提供参考。The artificial intelligence technology of computer science is widely used in digital pathology and develops rapidly,which is a milestone in the era of accurate diagnosis and treatment of tumors.As the gold standard of tumor diagnosis,traditional pathology is highly subjective and unrepeatable,and the work is cumbersome.Feature extraction and quantitative analysis of digital pathological images based on artificial intelligence technology are transformed into data with high fidelity and high-throughput that can be mined and analyzed.It shows unique advantages in early diagnosis,grading,and constructing the prognostic model of tumors.The development of artificial intelligence in digital pathology has brought a unique opportunity for pathology,and it is also the trend of the development of precise diagnosis and treatment in the future.In order to provide reference for clinical diagnosis and treatment,we review the current status and the value of potential application of artificial intelligence in digital pathological image analysis of colorectal cancer.

关 键 词：人工智能 深度学习 数字化病理 结直肠癌 

分 类 号：R735.3[医药卫生—肿瘤] TP183[医药卫生—临床医学]