苯并硒唑酮-多糖衍生物的合成及生物活性研究  

Study on the synthesis and bioactivities of benzoselenidone-polysaccharide derivatives

作　　者：薛亮 墨自营 张之金 江涛[1] XUE Liang;MO Zi-ying;ZHANG Zhi-jin;JIANG Tao(Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China)

机构地区：[1]中国海洋大学海洋药物教育部重点实验室,医药学院,山东青岛266003

出　　处：《中国海洋药物》2022年第3期64-68,共5页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金项目(82073759,82003583)资助。

摘　　要：目的 研究有机硒-多糖衍生物的人工合成方法及其生物活性。方法 以依布硒(Ebselen)的含硒基团为母核,对苯并硒唑酮-多糖衍生物进行化学合成。结果 合成了4种苯并硒唑酮-多糖衍生物,所用多糖有3种为海洋来源糖类,并测定了其中2种硒多糖对4种肿瘤细胞的增殖抑制活性,抑制率均超过80%。为苯并硒唑酮-多糖衍生物的合成及其活性研究提供了参考。Objective To study the synthesis and biological activities of organoselenium-polysaccharide derivatives. Methods Benzoselenidone-polysaccharide derivatives were synthesized by using the seleniumcontaining group of Ebselen as parent nucleus. Results Four benzoselenidone-polysaccharide derivatives were synthesized, among them, three polysaccharide moiety derived from marine resource. Two seleniumpolysaccharides exibited potent inhibitory on the proliferation against four tumor cell lines with the inhibitory rates over 80%. This study provided reference for the synthesis and bioactivity of benzoselenidonepolysaccharide derivatives.

关 键 词：有机硒-多糖衍生物 依布硒 硒多糖 

分 类 号：R914[医药卫生—药物化学]