Fascin lysine 471 acetylation cooperates with serine 39 phosphorylation to inhibit actin-bundling activity and tumor metastasis in esophageal squamous cell carcinoma  

作　　者：Fa-Min Zeng Yin-Wei Cheng Jian-Zhong He Xiu-E Xu Lian-Di Liao Li-Yan Xu En-Min Li 

机构地区：[1]Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area,Department of Biochemistry and Molecular Biology,Shantou University Medical College,Shantou,Guangdong 515041,P.R.China [2]Department of Pathology,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,Guangdong 519000,P.R.China [3]Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology,Institute of Basic Medical Science,Cancer Research Center,Shantou University Medical College,Shantou,Guangdong 515041,P.R.China

出　　处：《Cancer Communications》2022年第7期668-672,共5页癌症通讯（英文）

基　　金：supported by the grants from the National Natural Science Foundation of China(81872372);the Guangdong Basic and Applied Basic Research Foundation(2020A1515011532);the Natural Science Foundation of China-Guangdong Joint Fund(U0932001);the National Cohort of Esophageal Cancer of China(2016YFC0901400);the China Postdoctoral Science Foundation(2018M643134);2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant(2020LKSFG07B).

摘　　要：Dear Editor,Fascin actin-bundling protein 1(Fascin,gene name:FSCN1)is the primary actin-bundling protein that clusters filaments into stable and bundled filopodia[1].In previous studies,elevated levels of Fascin promoted filopodia formation and enhanced the invasive ability of tumor cells,suggesting that Fascin is a target for therapeutic intervention[2,3].Therefore,it is necessary to elucidate the detailed molecular mechanism by which Fascin bundles F-actin filaments.

关 键 词：FASCIN esophageal metastasis 

分 类 号：R73[医药卫生—肿瘤]