锌多糖的合成方法、结构特征和生物活性研究进展  

Progress of synthesis methods,structural characteristics and biological activities of zinc polysaccharides

作　　者：袁心田 陈华国[2,3] 赵超 龚小见[2,3] 周欣 YUAN Xintian;CHEN Huaguo;ZHAO Chao;GONG Xiaojian;ZHOU Xin(Guizhou University of Traditional Chinese Medicine,Guiyang 550002,China;Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment,Guizhou Normal University,Guiyang 550001,China;Guizhou Engineering Laboratory for Quality Control&Evaluation Technology of Medicine,Guizhou Normal University,Guiyang 550001,China)

机构地区：[1]贵州中医药大学,贵州贵阳550002 [2]贵州师范大学,贵州省山地环境信息系统与生态环境保护重点实验室,贵州贵阳550001 [3]贵州师范大学,贵州省药物质量控制及评价技术工程实验室,贵州贵阳550001

出　　处：《食品与发酵工业》2022年第14期336-344,共9页Food and Fermentation Industries

基　　金：贵州省高层次创新型人才培养项目(黔科合人才[2015]4033号);贵州师范大学2018年度学术新苗培养及创新探索专项项目(黔科合平台人才[2018]5769-27)。

摘　　要：锌是人体必需的微量元素之一,是人体中300多种酶的重要组成部分,其在蛋白质和DNA合成、细胞生长和增殖以及代谢调控等生理过程中起着重要作用。锌多糖是多糖与可溶性锌盐螯合后的络合物,具有高生物利用度、低毒性、易消化吸收等特点。锌多糖与多糖和无机锌相比,具有更好的抗氧化、降血糖、抗炎、抗癌、免疫调节、抗菌和保肝等活性,因此锌多糖可作为一种新型的补锌制剂进行研究与开发。该文简述了锌多糖的合成方法、结构特征分析方法和生物活性,指出了不同锌多糖研究中锌含量差异较大、结构较为复杂、生物活性研究范围较为局限以及缺乏临床实验数据等问题,并对锌多糖的应用前景进行展望,旨在为锌多糖的开发利用提供参考依据。Zinc is one of the essential trace elements for human health.It is also an important component of more than 300 enzymes,which plays an important role in physiological processes such as protein and DNA synthesis,cell growth and proliferation,and metabolic regulation.Moreover,zinc polysaccharide is a complex of polysaccharides chelated with soluble zinc salt,which has the characteristics of high bioavailability,low toxicity,easy digestion and absorption.Zinc polysaccharides could be used as a novel zinc supplementation due to its characteristics including antioxidant,hypoglycemic,anti-inflammatory,anti-cancer,immunomodulation,antibacterial and hepatoprotective compared with polysaccharides and inorganic zinc.This article briefly describes the synthesis methods,structural characterization methods and biological activities of zinc polysaccharides.Then,the problems such as large differences in zinc content in different zinc polysaccharides,complex structure,limitation of biological activity studies and lack of clinical experimental datawere pointed out.This article could provide an outlook on the application of zinc polysaccharides.

关 键 词：锌多糖 合成方法 结构特征 抗氧化 降血糖 

分 类 号：TS201.2[轻工技术与工程—食品科学]