围生期缺氧与孤独症谱系障碍的相关性研究进展  

Progress on the correlation between perinatal hypoxia and autism spectrum disorder

作　　者：田丁文(综述) 代英(审校)[1] Tian Dingwen;Dai Ying(Department of Health Care,Children′s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属儿童医院儿童保健科国家儿童健康与疾病临床医学研究中心儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室,400010

出　　处：《国际儿科学杂志》2022年第5期329-333,共5页International Journal of Pediatrics

基　　金：重庆市科卫联合医学科研项目 (2020MSXM075)。

摘　　要：孤独症谱系障碍(autism spectrum disorder,ASD)全球患病率为1%~1.5%,美国最新患病率为1.7%,成为全球患病数增速较快的疾病之一。近十年国内外学者关注到缺氧可以调节胎儿生长轨迹,增加包括ASD在内的多种神经系统疾病的发病风险。该文通过分析缺氧在ASD流行病学中的研究、缺氧的神经生物学与ASD的一致性、缺氧与ASD关联的可能机制,总结围生期缺氧与ASD患病情况的相关性。围生期缺氧可能从表观遗传学、多巴胺、炎症因子、氧化应激、类固醇多个方面影响患儿神经系统的发育与发展,最终增加ASD的患病风险。为评估孕期监护指标和制定干预提供重要参考,提前评估风险。通过早期诊治,改善患儿预后。The global prevalence rate of autism spectrum disorder(ASD)is 1%~1.5%,and the latest prevalence rate in the United States is 1.7%.ASD has become one of the diseases with rapid growth in the number of global diseases.In the past decade,scholars at home and abroad have noticed that hypoxia can regulate the fetal growth trajectory and increase the risk of a variety of neurological diseases,including ASD.This paper focuses on the correlation between perinatal hypoxia and the prevalence of ASD by analyzing hypoxia in epidemiology,the consistency between hypoxia neurobiology and ASD,and the possible mechanism of the association between hypoxia and ASD.Perinatal hypoxia may affect the development of children′s nervous system from epigenetics,dopamine,inflammatory factors,oxidative stress,steroids,and ultimately increase the risk of ASD.It provides an important reference for evaluating pregnancy monitoring indicators and formulating intervention,and evaluates early risk in advance.Early diagnosis and treatment can improve the prognosis of children.

关 键 词：孤独症谱系障碍 围生期缺氧 神经生物学 表观遗传学 

分 类 号：R74[医药卫生—神经病学与精神病学]