Polymersome-mediated cytosolic delivery of cyclic dinucleotide STING agonist enhances tumor immunotherapy  

作　　者：Huan Zheng Beibei Guo Xinyun Qiu Yifeng Xia Yan Qu Liang Cheng Fenghua Meng Zhiyuan Zhong 

机构地区：[1]Biomedical Polymers Laboratory,College of Chemistry,Chemical Engineering and Materials Science,and State Key Laboratory of Radiation Medicine and Protection,Soochow University,Suzhou,215123,PR China [2]Department of Pharmaceutics,College of Pharmaceutical Sciences,Soochow University,Suzhou,215123,PR China

出　　处：《Bioactive Materials》2022年第10期1-11,共11页生物活性材料（英文）

基　　金：supported by research grants from the National Natural Science Foundation of China(NSFC 52033006,51861145310,51773146 and 51633005)and the National Key R&D Program of China(2021YFB3800900).

摘　　要：Cyclic dinucleotides(CDNs)as stimulator of interferon genes(STING)agonists capable of inducing strong antitumor innate immune response are highly promising for tumor immunotherapy.The efficacy of these CDNs is,however,reduced greatly by their fast clearance,poor cell uptake and inefficient cytosolic transportation.Here,we report that reduction-responsive biodegradable chimaeric polymersomes(CPs)markedly enhance tumor retention and cytosolic delivery of a synthetic CDN,ADU-S100,and bolster STING pathway activation in the tumor microenvironment and tumor draining lymph nodes,giving significantly better tumor repression and survival of B16F10 melanoma-bearing mice compared with free CDN control.The superiority of CPs-mediated CDN delivery is further verified in combination therapy with low-dose fractionated radiation,which brings about clearly stronger and longer-term immunotherapeutic effects and protection against tumor re-challenge.The development of nano-STING agonists that are able to overcome the delivery barriers of CDNs represents an effective strategy to potentiate cancer immunotherapy.

关 键 词：POLYMERSOMES STING agonists Cyclic dinucleotide Immunotherapy Radiotherapy 

分 类 号：R73[医药卫生—肿瘤]