Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticles  

作　　者：Rui Zhao Tieliang Shang Bo Yuan Xiangdong Zhu Xingdong Zhang Xiao Yang 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu,610064,China

出　　处：《Bioactive Materials》2022年第11期379-393,共15页生物活性材料（英文）

基　　金：This project was funded by National Natural Science Foundation of China(grant no.81971755);Sichuan Science and Technology Program(2020YFS0038);Fundamental Research Funds for the Central Uni-versities.We thank Dr.Li Chen from the Analytical&Testing Center of Sichuan University for assistance with micro-CT images.

摘　　要：While most bone defects can be repaired spontaneously,the healing process can be complicated due to insuf-ficient bone regeneration when osteoporosis occurs.Synthetic materials that intrinsically stimulate bone for-mation without inclusion of exogenous cells or growth factors represent a highly desirable alternative to current grafting strategies for the management of osteoporotic defects.Herein,we developed a series of hydroxyapatite bioceramics composed of a microwhiskered scaffold(wHA)reinforced with multiple layers of releasable hy-droxyapatite nanoparticles(nHA).These novel bioceramics(nwHA)are tunable to optimize the loading amount of nHA for osteoporotic bone formation.The utility of nwHA bioceramics for the proliferation or differentiation of osteoporotic osteoblasts in vitro is demonstrated.A much more compelling response is seen when bioceramics are implanted in critical-sized femur defects in osteoporotic rats,as nwHA bioceramics promote significantly higher bone regeneration and delay adjacent bone loss.Moreover,the nwHA bioceramics loaded with a mod-erate amount of nHA can induce new bone formation with a higher degree of ossification and homogenization.Two types of osteogenesis inside the nwHA bioceramic pores were discovered for the first time,depending on the direction of growth of the new bone.The current study recommends that these tailored hybrid micro/nano-structured bioceramics represent promising candidates for osteoporotic bone repair.

关 键 词：Nano hydroxyapatite BIOCERAMICS OSTEOGENESIS Bone regeneration OSTEOPOROSIS 

分 类 号：R318.08[医药卫生—生物医学工程] R68[医药卫生—基础医学]