Dopaminergic Neurons in the Ventral Tegmental–Prelimbic Pathway Promote the Emergence of Rats from Sevoflurane Anesthesia  

作　　者：Yanping Song Ruitong Chu Fuyang Cao Yanfeng Wang Yanhong Liu Jiangbei Cao Yongxin Guo Weidong Mi Li Tong 

机构地区：[1]Anesthesia and Operation Center,The First Medical Center of Chinese,PLA General Hospital,Beijing 100853,China [2]Department of Anesthesia,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China [3]Chinese PLA Medical School,Beijing 100853,China [4]Department of Anesthesia,The Sixth Medical Center of Chinese,PLA General Hospital,Beijing 100048,China [5]Department of Anesthesia,Xiangya Hospital,Central South University,Changsha 410008,China

出　　处：《Neuroscience Bulletin》2022年第4期417-428,共12页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(81801366 and 82001453)and the National Key R&D Program of China(2018YFC2001901).

摘　　要：Dopaminergic neurons in the ventral tegmental area(VTA)play an important role in cognition,emergence from anesthesia,reward,and aversion,and their projection to the cortex is a crucial part of the"bottom-up"ascending activating system.The prelimbic cortex(PrL)is one of the important projection regions of the VTA.However,the roles of dopaminergic neurons in the VTA and the VTADA–PrL pathway under sevoflurane anesthesia in rats remain unclear.In this study,we found that intraperitoneal injection and local microinjection of a dopamine D1 receptor agonist(Chloro-APB)into the PrL had an emergence-promoting effect on sevoflurane anesthesia in rats,while injection of a dopamine D1 receptor antagonist(SCH23390)deepened anesthesia.The results of chemogenetics combined with microinjection and optogenetics showed that activating the VTADA–PrL pathway prolonged the induction time and shortened the emergence time of anesthesia.These results demonstrate that the dopaminergic system in the VTA has an emergence-promoting effect and that the bottom-up VTADA–PrL pathway facilitates emergence from sevoflurane anesthesia.

关 键 词：Ventral tegmental area Prelimbic cortex DOPAMINE SEVOFLURANE General anesthesia 

分 类 号：R614[医药卫生—麻醉学]