White Matter“Matters”in Alzheimer’s Disease  

作　　者：Man-Yu Xu Zhi-Qiang Xu Yan-Jiang Wang 

机构地区：[1]Department of Neurology and Center for Clinical Neuroscience,Daping Hospital,Third Military Medical University,Chongqing,400042,China [2]Chongqing Key Laboratory of Ageing and Brain Diseases,Chongqing,400042,China [3]The Institute of Brain and Intelligence,Third Military Medical University,Chongqing,400042,China

出　　处：《Neuroscience Bulletin》2022年第3期323-326,共4页神经科学通报（英文版）

基　　金：National Natural Science Foundation of China(81930028,31921003,91749206,and 81625007)。

摘　　要：Alzheimer's disease(AD)is a neurodegenerative disease that increasingly burdens many families worldwide.Although AD is generally thought to be closely associated with gray matter,many studies have identified significant changes in white matter as well,including demyelination and function alterations in oligodendrocytes in the AD brain.In addition,Ap plaques,the most important pathological characteristic in AD,are deposited in late-myelinating regions such as the prefrontal and temporal lobes,where myelin is prone to damage[1].All the evidence hints that the changes in myelin are closely associated with the onset and progression of AD,prompting scientists to outline the process of changing myelin in AD and develop novel strategies for the treatment of AD.

关 键 词：ALZHEIMER alterations DAMAGE 

分 类 号：R749.4[医药卫生—神经病学与精神病学]