Correlation study between dendritic cell and eosinophil in refractory rhinosinusitis  

作　　者：Yin-Ping Zeng Zhong-Lin Mu Shun Ding Zhi-Fei Luo 

机构地区：[1]First Affiliated Hospital of Hainan Medical University Department of Otorhinolaryngology Head and Neck Surgery,Haikou 570102,China [2]First Affiliated Hospital of Hainan Medical University Department of Pathology,Haikou 570102,China

出　　处：《Journal of Hainan Medical University》2022年第11期18-23,共6页海南医学院学报（英文版）

基　　金：Youth Cultivation Fund Project of the First Affiliated Hospital of Hainan Medical College(No.HYFYPY201815);National Natural Science Foundation of China(No.81660171);High Level Talents Project of Hainan Natural Science Foundation(No.820RC627)。

摘　　要：Objective:To investigate the correlation of refractory rhinosinusitis by detecting the expression of dendritic cells and eosinophils infiltration in nasal mucosa.Methods:Histological staining was performed to detect eosinophils infiltration respectively in 30 normal nasal mucosa,30 chronic rhinosinusitis tissues and 30 refractory rhinosinusitis tissues,Immunohistochemistry and immunofluorescence double labeling were performed to detect the expression of CD83 and CD11c in each group,and univariate anova was used to analyze the differences among groups.The correlation between the co-expression of CD83 and CD11c and the infiltration of eosinophilic cells was measured by Pearson correlation analysis.Results:The positive expression of dendritic cells immune markers CD83 and CD11c and eosinophils infiltration of refractory rhinosinusitis was significantly increased compared with the other two groups(P<0.05).Through Pearson correlation analysisthe,correlation coefficient r between CD83 and CD11c co-expression and eosinophils infiltration in each group was positive and P<0.05,both were positively correlated.Conclusion:The number of dendritic cells in refractory rhinosinusitis increased significantly and was positively correlated with the infiltration of eosinophils,which was involved in the development of refractory rhinosinusitis.

关 键 词：Refractory rhinosinusitis EOSINOPHIL Dendritic cell 

分 类 号：R73[医药卫生—肿瘤]