Effects of DNA damage on oocyte meiotic maturation and early embryonic development  

作　　者：Shen YIN Junyu MA Wei SHEN 

机构地区：[1]Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong,College of Animal Science and Technology,Qingdao Agricultural University,Qingdao 266109,China

出　　处：《Frontiers of Agricultural Science and Engineering》2014年第3期185-190,共6页农业科学与工程前沿（英文版）

基　　金：This study was supported by the National Natural Science Foundation of China(31171376 and 31401276);National Basic Research Program of China(2012CB944401).

摘　　要：DNA damage is one of the most common threats to meiotic cells.It has the potential to induce infertility and genetic abnormalities that may be passed to the embryo.Here,we reviewed exogenous factors which could induce DNA damage.Specially,we addressed the different effects of DNA damage on mouse oocytes and embryonic development.Complex DNA damage,doublestrand breaks,represents a more difficult repair process and involves various repair pathways.Understanding the mechanisms involved in DNA damage responses may improve therapeutic strategies for ovarian cancer and fertility preservation.

关 键 词：DNA damage double-strand breaks(DSBs) OOCYTE EMBRYO 

分 类 号：R73[医药卫生—肿瘤]