蜂王浆泡腾片的制备及王浆酸溶出的测定  

Preparation of Royal Jelly Effervescent Tablets and Determination of 10-HDA Dissolution

作　　者：沈文 吴立新 刘树兴 延梦瑶 SHEN Wen;WU Lixin;LIU Shuxing;YAN Mengyao(School of Food and Biolohical Engineering,Shaanxi University of Science&Technology,Xi'an 710021,China)

机构地区：[1]陕西科技大学食品与生物工程学院,陕西西安710021

出　　处：《食品工业科技》2022年第14期276-282,共7页Science and Technology of Food Industry

基　　金：陕西省科技厅重点研发计划项目(2020SF-423,2020FP-029,2021SF-339)。

摘　　要：目的:为解决蜂王浆泡腾片中难溶成分10-羟基-2-癸烯酸(10-HDA)溶出率低的问题。方法:采用单因素实验和正交试验,研究了泡腾剂添加量、泡腾剂比例(柠檬酸:碳酸氢钠)、甜味剂添加量对蜂王浆泡腾片崩解时间及产气量的影响,并探索了不同食品添加剂对蜂王浆泡腾片中10-HDA溶出度的影响,获得了最佳配方。同时,利用X射线衍射(XRD)表征蜂王浆泡腾片的结晶度。结果:最佳配方为蜂王浆冻干粉10%,泡腾剂添加量45%,泡腾剂最佳比例(柠檬酸:碳酸氢钠)=1.5:1,甘露醇10%,罗汉果甜苷1%,硬脂酸镁0.8%,15%乳酸钙或者0.5%聚甘油脂肪酸酯,剩余以乳糖填充至100%。该配方下制得的蜂王浆泡腾片,口感良好、崩解迅速,并有效提高了10-HDA的溶出率,10-HDA的累计溶出率在15 min左右可使达到85%以上。结论:在蜂王浆泡腾片配方中加入乳酸钙或聚甘油脂肪酸酯可以有效提高10-HDA的溶出率,为提高蜂王浆相关产品中10-HDA溶出率提供了数据参考。Objective:To solve the problem of low dissolution rate of 10-hydroxy-2-decenoic acid(10-HDA)in royal jelly effervescent tablets.Methods:The disintegration time and gas production were used as evaluation indexes.Single factor experiments and orthogonal test were used to optimize the amount of effervescent agent,the ratio of effervescent agent(citric acid:NaHCO_(3)),and the amount of sweetener added.Then different food additives were added to the formula.The effect of different food additives on the dissolution of 10-HDA was explored.And the optimum formula was obtained.Meanwhile,X-ray diffraction(XRD)was used to characterize the crystallinity of royal jelly effervescent tablets.Results:The optimum formula were royal jelly lyophilized powder 10%,effervescent agent 45%,best effervescent ratio(citric acid:NaHCO_(3))=1.5:1,mannitol 10%,mogroside 1%,and magnesium stearate 0.8%,15%calcium lactate or 0.5%polyglycerol fatty acid ester,and the rest was filled with lactose to 100%.The royal jelly effervescent tablets prepared by the formula had a good taste and rapid disintegration.In about 15 minutes,the cumulative dissolution rate of 10-HDA could reach 85%or more.Conclusion:Adding calcium lactate or polyglycerol fatty acid ester to the royal jelly effervescent tablets’formulation could effectively improve the dissolution rate of 10-HDA.This study provided data reference for improving 10-HDA dissolution rate in royal jelly related products.

关 键 词：蜂王浆泡腾片 崩解时间 食品添加剂 10-HDA溶出率 

分 类 号：TS201.1[轻工技术与工程—食品科学]