基于HS-SPME-GC-MS技术分析安神药对柏子仁-酸枣仁中的挥发性成分  

Analysis of Volatile Components in Drug Pairs of Seman Platycladi-Semen Ziziphi Spinosae by HS-SPME-GC-MS

作　　者：郭胜男 文婷 卢金清[3] Guo Shengnan;Wen Ting;Lu Jinqing(Department of Pharmacy,Wuhan Mental Health Center,Wuhan 430012,China;Department of Pharmacy,Wuhan Hospital for Psychotherapy;Hubei University of Chinese Medicine/Research and Development Center of Medicinal Plant in Hubei Province)

机构地区：[1]武汉市精神卫生中心药学部,武汉430012 [2]武汉市心理医院药学部 [3]湖北中医药大学/湖北省药用植物研发中心

出　　处：《中国药师》2022年第6期1091-1095,共5页China Pharmacist

摘　　要：目的:对传统药对柏子仁-酸枣仁挥发性成分进行分析,探讨其挥发性成分的药效物质基础。方法:利用单因素考察来确定最佳萃取条件,采用顶空-固相微萃取(HS-SPME)技术结合气相色谱-质谱联用法(GC-MS),测定柏子仁-酸枣仁药对的挥发性成分和相对百分含量。结果:从柏子仁-酸枣仁药对中分离出80个峰,并鉴定了其中71种挥发性成分。结论:柏子仁-酸枣仁药对的挥发性成分主要组成为萜烯类、醇类和烷烃类。Objective: To analyze the volatile components in drug pairs of Seman Platycladi-Semen Ziziphi Spinosae to explore the pharmacodynamic material basis of volatile components. Methods: The optimum extraction conditions were determined by single factor investigation, and HS-SPME combined with GC-MS was used to determine the volatile components and their relative percentages in the drug pair. Results: Totally 80 peaks were isolated from the drug pair of Seman Platycladi-Semen Ziziphi Spinosae, and 71 volatile components were identified. Conclusion: The volatile components in the drug pair of Seman Platycladi-Semen Ziziphi Spinosae are mainly terpenes, alcohols and alkanes.

关 键 词：顶空-固相微萃取 气相色谱-质谱联用 安神药对 柏子仁-酸枣仁 挥发性成分 

分 类 号：R284.1[医药卫生—中药学]