Programmable Oligonucleotide-Peptide Complexes:Synthesis and Applications  

作　　者：XU Min ZHOU Baomei DING Yan DU Shanshan SU Mengke LIU Honglin 

机构地区：[1]China Light Industry Key Laboratory of Meat Microbial Control and Utilization,School of Food and Biological Engineering,Hefei University of Technology,Hefei,230009,P.R.China [2]First Affiliated Hospital of Anhui Medical University,Hefei,230000,P.R.China

出　　处：《Chemical Research in Chinese Universities》2022年第4期856-865,共10页高等学校化学研究（英文版）

基　　金：supported by the National Key Research and Development Program of China(No.2019YFC1605900);the National Natural Science Foundation of China(Nos.21922403,21874034);the Key Research and Development Project of Anhui Province,China(No.202104a07020013);the Fundamental Research Funds for the Central Universities,China(Nos.PA2020GDJQ0030,JZ2021HGTA0171,JZ2021HGQA0243);the Anhui Provincial Natural Science Foundation,China(No.2108085QB84).

摘　　要：Nucleic acids form biological blueprint and polypeptides assist life activities,both of which are indispensable to organisms.Recently,oligonucleotide-peptide complexes(OPCs)have shown great potential in biomedicine,material chemistry and other fields due to their considerable stability and programmability.It remains a huge challenge to stably and facilely constructing OPCs that also limits the wide applications.This tutorial review first summarizes the synthesis strategies of OPC conjugation and the corresponding characteristics in detail,then gives examples of the applications of OPCs,and finally presents a prospective overview on challenges and future perspectives of OPCs.This review aims to help researchers understand the current situation and challenges in this field,thereby furthering interests in developing novel OPC synthesis techniques.

关 键 词：OLIGONUCLEOTIDE PEPTIDE COMPLEX 

分 类 号：O62[理学—有机化学]