OLIGONUCLEOTIDE

作品数：101被引量：206H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：潘世扬刘锋何昆束永前汤新景更多>>
相关机构：北京大学首都医科大学南京医科大学中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>
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Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in a Macrophage-Specific and Liver-Specific Manner
《Engineering》2024年第10期189-203,共15页Hengdong Qu Di Zhang Junli Liu Jieping Deng Ruoyan Xie Keke Zhang Hongmei Li Ping Tao Genshu Wang Jian Sun Oscar Junhong Luo Chen Qu Wencai Ye Jian Hong 
supported by the Key-Area Research and Development Program of Guangdong Province(2020B1111110004);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036);the Guangdong Major Project of Basic and Applied Basic Research(2023B0303000004);the National Natural Science Foundation of China(81871987,82293680,82293681,and 82273154);the Guangdong Basic and Applied Research Foundation(2023A1515012905 and 2022A1515012581)。
Nonalcoholic steatohepatitis(NASH)may soon become the leading cause of end-stage liver disease worldwide with limited treatment options.Liver fibrosis,which is driven by chronic inflammation and hepatic stellate cell(...
关键词：Pyruvate kinase M2 MACROPHAGES Nonparenchymal cells Heteroduplex oligonucleotide Nonalcoholic steatohepatitis Liver fibrosis 
Polyelectrolyte Complexes and Coacervates Formed by De novo-Designed Peptides and Oligonucleotide
《Chinese Journal of Polymer Science》2024年第9期1333-1340,I0007,共9页Tian-Hao Ren De-Hai Liang 
supported by the National Natural Science Foundation of China(No.21973002).
The liquid-liquid phase separation of biopolymers in living cells contains multiple interactions and occurs in a dynamic environment.Resolving the regulation mechanism is still a challenge.In this work,we designed a s...
关键词：Polyelectrolyte complex COACERVATE PEPTIDES Secondary structure Electrostatic interaction 
Current status and trends in small nucleic acid drug development:Leading the future被引量：1
《Acta Pharmaceutica Sinica B》2024年第9期3802-3817,共16页Yuxi Miao Chen Fu Zhaojin Yu Lifeng Yu Yu Tang Minjie Wei 
the National Natural Science Foundation of China(NSFC,No.82272797);the National Natural Science Foundation of China(NSFC,No.82304564);Shenyang Young and Middle-aged Scientific and Technological Innovation Talents Support Project(No.RC220508,China).
Small nucleic acid drugs,composed of nucleotides,represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based therapeutics.These agents function by selective...
关键词：Small nucleic acid drugs Oligonucleotide drugs siRNA ASO miRNA APTAMER RNAi Drug development 
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma
《Acta Pharmacologica Sinica》2024年第8期1701-1714,共14页Qi-yi Zhang Wen Ding Jian-shan Mo Shu-min Ou-yang Zi-you Lin Ke-ren Peng Guo-pin Liu Jin-jian Lu Pei-bin Yue Jin-ping Lei Yan-dong Wang Xiao-lei Zhang 
supported by the National Natural Science Foundation of China(22077144,81973359);Guangdong Basic and Applied Basic Research Foundation(2022A1515012204);Joint Foundation of Guangdong and Macao for Science and Technology Innovation(2022A0505020024);the Science and Technology Development Fund,Macao SAR(File No.0053-2021-AGJ);The Key Research and Development Plan of Guangzhou City(202206080007);Guangdong Provincial Key Laboratory of Construction Foundation(2023B1212060022)are also appreciated.
Signal transducer and activator of transcription 3(STAT3)plays an important role in the occurrence and progression of tumors,leading to resistance and poor prognosis.Activation of STAT3 signaling is frequently detecte...
关键词：STAT3 antisense oligonucleotide hepatocellular carcinoma acquired sorafenib-resistance 
MicroRNA-206 functions as a potential oligonucleotide therapeutics in preterm birth
《Chinese Medical Journal》2024年第8期1000-1002,共3页Wenfeng Deng Lina Chen Bolun Wen Xiaodi Wang Lele Wang Fan Yang Yunshan Chen Junjie Bao Guozheng Zhang Kaiyuan Ji Huishu Liu 
National Natural Science Foundation of China(No.81871181);High-tech Major Featured Technology Program of Guangzhou Municipal Health Commission(No.2019GX07)
To the Editor:Spontaneous preterm labor(PTL)causes infant morbidity and mortality.Regular uterine contractions were the common characteristics in spontaneous labor at term or PTL.Thus,effective decrease or suppression...
关键词：MORTALITY CONTRACTION RU486 
Engineered smart materials for RNA based molecular therapy to treat Glioblastoma
《Bioactive Materials》2024年第3期396-423,共28页Ravi Raj Singh Indranil Mondal Taskeen Janjua Amirali Popat Ritu Kulshreshtha 
funding from Industrial Research and Development(IRD)unit of the Indian Institute of Technology Delhi under the IRD-MFIRP scheme(MI02697G);also acknowledge the Science and Engineering Research Board(SERB),Goverment of India,for the financial support(CRG/2020/004640).
Glioblastoma(GBM)is an aggressive malignancy of the central nervous system(CNS)that remains incurable despite the multitude of improvements in cancer therapeutics.The conventional chemo and radiotherapy post-surgery h...
关键词：Glioblastoma(GBM) Non-coding RNAs(ncRNA) Nucleic acid therapy Oligonucleotide therapy NANOCARRIERS Nanoparticles RNA delivery system Gene therapy 
Potential oligonucleotide drugs in Bencao sRNA Atlas
《Science China(Life Sciences)》2023年第12期2943-2945,共3页Fengming Huang Jiaqi Liu Sifen Du Yexuan Lin Chengyu Jiang 
Dear Editor,We read the Letter of Professor Shanfa Lu(Lu,2023)titled“Are herbal sRNAs really novel precision medicines?”In this Letter,Lu(2023)commented on our previously published manuscripts(Du et al.,2019;Huang e...
关键词：REALLY LETTER ATLAS 
Oral administration of the herbal oligonucleotide XKC-sRNA-h3 prevents angiotensinⅡ-induced hypertension in mice被引量：5
《Science China(Life Sciences)》2023年第10期2370-2379,共10页Kegong Tang Xiaona Wang Yu Zhao Xiaobei Li Zhenyu Jiang Song Mei Mingrui Chen Yiming Ma Xinyi Du Xiangyu Qiao Na Sun Jiaqi Liu Chengyu Jiang 
the National Natural Science Foundation of China(81788101);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-022);the 111 Project(BP0820029);the CAMS Endowment Fund(2021-CAMSJZ001)。
Hypertension has become a growing public health concern worldwide.In fact,hypertension is commonly associated with increased morbidity and mortality.Currently,oligonucleotide drugs have proven to be promising therapeu...
关键词：HYPERTENSION oligonucleotide drug oral administration 
A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases被引量：7
《Science China(Life Sciences)》2023年第10期2380-2398,共19页Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang 
the National Natural Science Foundation of China(81788101,32100104);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1022);the CAMS Endowment Fund(2021-CAMS-JZ001);the Overseas Expertise Introduction Center for Discipline Innovation(“111 Center”)(BP0820029)。
Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique ...
关键词：small RNA herbal decoction cross-kingdom regulation traditional Chinese medicine RNA oligonucleotide drug RNA therapeutics Bencao small RNA Atlas 
Orally administered BZL-s RNA-20 oligonucleotide targeting TLR4 effectively ameliorates acute lung injury in mice被引量：7
《Science China(Life Sciences)》2023年第7期1589-1599,共11页Dandan Zhao Yuhao Qin Jiaqi Liu Kegong Tang Shuaiyao Lu Zirui Liu Yexuan Lin Cong Zhang Fengming Huang Jiahui Chang Chang Li Mingyao Tian Yiming Ma Xiaoyun Li Congzhao Zhou Xiao Li Xiaozhong Peng Ningyi Jin Chengyu Jiang 
supported by the National Natural Science Foundation of China(81788101);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-022);the CAMS Endowment Fund(2021-CAMS-JZ001);the Overseas Expertise Introduction Center for Discipline Innovation(“111Center”)(BP0820029);the State Key Laboratory Special Fund of State Key Laboratory of Medical Molecular Biology(2060204)。
The global COVID-19 pandemic emerged at the end of December 2019.Acute respiratory distress syndrome(ARDS)and acute lung injury(ALI)are common lethal outcomes of bacterial lipopolysaccharide(LPS),avian influenza virus...
关键词：oligonucleotide drug herbal medicine ARDS/ALI SARS-CoV-2 
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