Patient-directed vs.fixed-volume PEG for colonoscopy preparation:a randomized controlled trial  

作　　者：Jixiang Zhang Xuemei Jia Yuanmei Guo Haotian Jiang Jiaming Hu Siwei Wang Binglu Huang Wenhao Su Jun Liu Xiaoli Wang Weiguo Dong 

机构地区：[1]Department of Gastroenterology,Renmin Hospital of Wuhan University,Wuhan 430060,China [2]Digestive Endoscopy Center,Renmin Hospital of Wuhan University,Wuhan 430060,China [3]Department of Hematology,Huashan Hospital of Fudan University,Shanghai 200433,China [4]Department of Hematology,Renmin Hospital of Wuhan University,Wuhan 430060,China [5]Department of Plastic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China

出　　处：《Precision Clinical Medicine》2022年第2期117-124,共8页精准临床医学（英文）

基　　金：supported from the National Natural Science Foundation of China(Grants No.82000521 and 82102797).

摘　　要：Background:Individualization using different volumes of polyethylene glycol is widely regarded as the optimal solution for bowel preparation,while the patient-directed regimen we propose may serve as a reliable individual solution.This study aimed to assess the efficacy,safety,and satisfaction of bowel preparation with a patient-directed regimen.Methods:Patients in the fixed-volume group ingested the same amount of PEG,while those in patient-directed group ingested different amount according to stool consistency or stool water content.Results:After filtering by exclusion criteria,428 individuals in the fixed-volume group and 103 in the patient-directed group were successfully enrolled and analyzed.Eighty-three(80.6%)individuals in the patient-directed group had a reduced polyethylene glycol volume.There was no significant difference in the bowel preparation efficacy between the two groups(90.0%vs.90.3%,χ^(2)=0.01;p=0.918).Patients in the patient-directed group complained of fewer adverse effects(53.0%vs.36.9%,χ^(2)=8.655;p=0.003),especially vomiting(13.6%vs.1.0%,χ^(2)=13.304;p<0.001).Regarding comfort during bowel preparation,the degree of comfort was not significantly different between groups.Furthermore,the willingness rate for further colonoscopy in the patient-directed group was significantly higher than that in the fixed-volume group(90.3%vs.77.1%,χ^(2)=8.912;p<0.05).Multivariable logistic regression analysis showed that the body mass index served as an independent factor impacting quality of bowel preparation with the patient-directed regimen(OR 1.16,95%CI 1.00–1.34;p=0.043).Conclusions:Without decreasing the bowel preparation efficacy,the patient-directed regimen increased the safety and satisfaction of bowel preparation and is expected to be a regular and individual solution for bowel preparation.Individuals with a lower body mass index are more likely to undertake this new regimen.

关 键 词：bowel preparation patient-directed INDIVIDUALIZATION EFFICACY safety 

分 类 号：R57[医药卫生—消化系统]