Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets  

作　　者：Liang Wang Wen-Tao Hou Jie Wang Da Xu Cong Guo Linfeng Sun Ke Ruan Cong-Zhao Zhou Yuxing Chen 

机构地区：[1]The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui,China [2]School of Life Sciences,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui,China

出　　处：《Cell Research》2022年第5期501-504,共4页细胞研究（英文版）

基　　金：the Ministry of Science and Technology of China(2019YFA0508500);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37020202);the Fundamental Research Funds for the Central Universities(YD20700002005).

摘　　要：Dear Editor,Bile acids are a group of cholesterol-derived physiological surfactants required for digestion of lipids and fat-soluble vitamins.1However,excess of bile acids is detrimental to metabolic homeostasis and bile acid imbalance can contribute to cancer progression.2Bile acids are produced primarily in the liver and then secreted to the bile duct before delivery to the small intestine,where up to 95%of bile acids are reabsorbed and recirculated to the liver(Supplementary information,Fig.S1a).The primary bile acids are biosynthesized in hepatocytes via oxidation of cholesterol and modified by either taurine or glycine,forming the conjugated primary bile acids which harbor a cholic acid moiety and a taurine/glycine moiety(Supplementary information,Fig.S1 b).This enterohepatic circulation of bile acids is driven by a series of transmembrane transporters(Supplementary informa-tion,Fig.S1a),including the ATP-binding cassette(ABC)transpor-ter ABCB11(also termed bile salt export pump BSEP).

关 键 词：BILE VITAMIN INTESTINE 

分 类 号：R57[医药卫生—消化系统]