Novel index for the prediction of significant liver fibrosis and cirrhosis in chronic hepatitis B patients in China  

作　　者：Min-Jun Liao Jun Li Wei Dang Dong-Bo Chen Wan-Ying Qin Pu Chen Bi-Geng Zhao Li-Ying Ren Ting-Feng Xu Hong-Song Chen Wei-Jia Liao 

机构地区：[1]Laboratory of Hepatobiliary and Pancreatic Surgery,The Affiliated Hospital of Guilin Medical University,Guilin 541001,Guangxi Zhuang Autonomous Region,China [2]Guangdong Provincial Key Laboratory of Gastroenterology,Department of Gastroenterology and Hepatology Unit,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong Province,China [3]Genetics and Precision Medicine Laboratory,The Affiliated Hospital of Guilin Medical University,Guilin 541001,Guangxi Zhuang Autonomous Region,China [4]Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease,Peking University People’s Hospital,Beijing 100044,China

出　　处：《World Journal of Gastroenterology》2022年第27期3503-3513,共11页世界胃肠病学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China,No.81372163;the Natural Science Foundation of Guangxi,No.2018GXNSFDA138001;the Science and Technology Planning Project of Guilin,No.20190218-1;the Opening Project of Key laboratory of High-Incidence-Tumor Prevention&Treatment(Guangxi Medical University),Ministry of Education,No.GKE-KF202101;the Program of Guangxi Zhuang Autonomous Region Health and Family Planning Commission,No.Z20210706 and No.Z20190665。

摘　　要：BACKGROUND Noninvasive,practical,and convenient means of detection for the prediction of liver fibrosis and cirrhosis in China are greatly needed.AIM To develop a precise noninvasive test to stage liver fibrosis and cirrhosis.METHODS With liver biopsy as the gold standard,we established a new index,[alkaline phosphatase(U/L)+gamma-glutamyl transpeptidase(U/L)/platelet(109/L)(AGPR)],to predict liver fibrosis and cirrhosis.In addition,we compared the area under the receiver operating characteristic curve(AUROC)of AGPR,gammaglutamyl transpeptidase to platelet ratio,aspartate transaminase to platelet ratio index,and FIB-4 and evaluated the accuracy of these routine laboratory indices in predicting liver fibrosis and cirrhosis.RESULTS Correlation analysis revealed a significant positive correlation between AGPR and liver fibrosis stage(P<0.001).In the training cohort,the AUROC of AGPR was 0.83(95%CI:0.78-0.87)for predicting fibrosis(≥F2),0.84(95%CI:0.79-0.88)for predicting extensive fibrosis(≥F3),and 0.87(95%CI:0.83-0.91)for predicting cirrhosis(F4).In the validation cohort,the AUROCs of AGPR to predict≥F2,≥F3 and F4 were 0.83(95%CI:0.77-0.88),0.83(95%CI:0.77-0.89),and 0.84(95%CI:0.78-0.89),respectively.CONCLUSION The AGPR index should become a new,simple,accurate,and noninvasive marker to predict liver fibrosis and cirrhosis in chronic hepatitis B patients.

关 键 词：Liver FIBROSIS CIRRHOSIS PREDICTION Novel noninvasive marker Chronic hepatitis B 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]