Stem cells in intervertebral disc regeneration-more talk than action?  

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作  者:PETRA KRAUS ANKITA SAMANTA SINA LUFKIN THOMAS LUFKIN 

机构地区:[1]Department of Biology,Clarkson University,Potsdam,NY 13699,USA [2]The Clarkson School,Clarkson University,Potsdam,NY 13699,USA

出  处:《BIOCELL》2022年第4期893-898,共6页生物细胞(英文)

基  金:supported by the Bayard and Virginia Clarkson Endowment Fund and NIH HD099588 both granted to Thomas Lufkin.

摘  要:Pain and lifestyle changes are common consequences of intervertebral disc degeneration(IVDD)and affect a large part of the aging population.The stemness of cells is exploited in the field of regenerative medicine as key to treat degenerative diseases.Transplanted cells however often face delivery and survival challenges,especially in tissues with a naturally harsh microniche environment such as the intervertebral disc.Recent interest in the secretome of stem cells,especially cargo protected from microniche-related decay as frequently present in degenerating tissues,provides new means of rejuvenating ailing cells and tissues.Exosomes,a type of extracellular vesicles with purposeful cargo gained particular interest in conveying stem cell related attributes of rejuvenation,which will be discussed here in the context of IVDD.

关 键 词:Stem cells MSC Intervertebral disc(IVD) EXOSOME Extracellular matrix(ECM) 

分 类 号:R73[医药卫生—肿瘤]

 

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