The versatility of mesenchymal stem cells:From regenerative medicine to COVID,what is next?  

作　　者：THAÍS CASAGRANDE PAIM MÁRCIA ROSÂNGELA WINK 

机构地区：[1]Laboratório de Biologia Celular,Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA),Porto Alegre,90050-170,Brazil

出　　处：《BIOCELL》2022年第4期913-922,共10页生物细胞（英文）

基　　金：This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil(CAPES)-Finance Code 001;TCP is fellowship from PhD CAPES(Coordenação de Aperfeiçoamento de Pessoal de Nível Superior);MRW is recipient of 1D level research fellowship from CNPq(Conselho Nacional de Desenvolvimento Científico e Tecnológico);This study was supported by CNPq,MS-SCTIE-Decit/CNPq no 12/2018(441575/2018-8);MSSCTIE-DECIT-DGITIS-CGCIS/CNPq no 26/2020(442586/2020-5);by Fundação de AmparoàPesquisa do Estado do Rio Grande do Sul-Brasil(FAPERGS/CAPES 06/2018-Programa de Internacionalização da pós-graduação no RS(19/2551-0000679-9).

摘　　要：Mesenchymal stem cells(MSCs)play key roles in regenerative medicine by promoting tissue healing.MSCs can be isolated from different adult tissues and they are able to differentiate into several lineages.Due to their antiinflammatory,angiogenic and immune-modulatory properties,MSCs are suitable for tissue engineering applications and,when associated with biomaterials,their benefits can be improved.Moreover,recently,MSCs have been studied for new clinical applications,such as in the treatment of patients with COVID-19.MSCs regenerative potential has been attributed to their secretome,which comprises extracellular matrix,soluble proteins and several elements,including the release of extracellular vesicles.Even though,in order to explore all their therapeutic potential,it is still necessary to advance in the investigation of their basic cell biology characteristics.

关 键 词：Mesenchymal stem cells Regenerative medicine SECRETOME BIOMATERIALS Extracellular vesicles 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]