Cell extrusion in development and cancer,what MARCKS the difference for epithelial integrity?  

作　　者：LUCÍA VELOZ SANTIAGO A.BOSCH GONZALO APARICIO FLAVIO R.ZOLESSI 

机构地区：[1]Sección Biología Celular,Facultad de Ciencias,Universidad de la República,Montevideo,CP 11400,Uruguay [2]Institut Pasteur de Montevideo,Montevideo,CP 11400,Uruguay [3]Sección Biofísica y Biología de Sistemas,Facultad de Ciencias,Universidad de la República,Montevideo,CP 11400,Uruguay

出　　处：《BIOCELL》2022年第3期639-644,共6页生物细胞（英文）

基　　金：This work was partially funded by CSICUdelaR Grant C125-347 to FRZ;CAP-UdelaR Master’s fellowship to SAB;Dedicación Total-UdelaR,to FRZ;PEDECIBA.

摘　　要：Cell extrusion is an active mechanism to eliminate non-viable or supernumerary cells in healthy epithelia.It also plays a role in carcinogenesis,both in tumor growth(apical extrusion)and metastasis(basal extrusion).Embryonic tissues like the neuroepithelium,on the other hand,present rates of proliferation comparable to that of carcinomas,without the occurrence of cell extrusion.However,the downregulation or phosphorylation of actinmodulating proteins like MARCKS,causes extensive neuroepithelial apical cell extrusion.As changes in MARCKS proteins phosphorylation and expression have also been correlated to carcinogenesis,we propose here an integrated model for their functions in epithelial integrity.

关 键 词：Epithelial-mesenchymal plasticity Carcinoma NEURULATION NEUROEPITHELIUM PHOSPHORYLATION 

分 类 号：R73[医药卫生—肿瘤]