冷链定位系统在新生儿遗传代谢病筛查样本运输中的应用  

Application of cold chain positioning system in transport of neonatal inherited metabolic disease screening samples

作　　者：吴璀璐 杨建滨[1] 徐益红[1] 徐艳华[1] 杨茹莱[1] 毛华庆[1] WU Cuilu;YANG Jianbin;XU Yihong;XU Yanhua;YANG Rulai;MAO Huaqing(Department of Genetics and Metabolism,Children's Hospital Affiliated to Zhejiang University School of Medicine(National Clinical Research Center for Child Health),Hangzhou,Zhejiang 310052,China)

机构地区：[1]浙江大学医学院附属儿童医院遗传与代谢科(国家儿童健康与疾病临床医学研究中心),浙江杭州310052

出　　处：《预防医学》2022年第8期852-854,862,共4页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：浙江省重点研发计划(2021C03099)。

摘　　要：滤纸干血斑样本运输是新生儿遗传代谢病筛查的关键环节,对于筛查结果的准确性具有重要意义。为保障样本运输的及时性和安全性,浙江省新生儿疾病筛查中心研发了冷链定位系统并于2015年3月启用。该系统基于新生儿疾病筛查信息管理系统框架,嵌入物流运输管理系统功能,利用联通4G物联网卡和GPS/北斗卫星实时定位样本运输箱,实现样本运输过程的监控和追溯;采用5℃相变蓄冷材料制作的温控箱和GPRS温度记录仪,确保样本处于2~8℃的运输环境。应用冷链定位系统后,样本检测前周转时间由平均8.44 d缩短为5.03 d;样本递送及时率由31.69%提升至77.90%,不合格样本退片率由0.12%下降至0.08%。冷链定位系统很好地满足了滤纸干血斑样本运输要求,在新生儿遗传代谢病筛查领域具有较好的应用前景。Transport of filter paper-dried blood spot samples is a critical procedure during the screening of neonatal in⁃herited metabolic diseases,which is of great significance for the screening accuracy.In order to ensure the timing and safety of sample transport,the cold chain positioning system was initiated by Zhejiang Provincial Center for Quality Con⁃trol of Neonatal Disease Screening since March 2015.Based on the framework of neonatal disease screening information management system,the function of the logistics transport management system was included in this positioning system,with aims to achieve the monitoring and tracking of sample transport processes through real-time positioning of the sam⁃ple transport box via China Unicom 4G logistics card and global positioning system/BeiDou Navigation Satellite System.The samples are maintained in a transport environment at 2 to 8°C via the temperature-controlled box made of 5°C phase-changed cold-stored materials and general packet radio service(GPRS)temperature recorders.The mean pretest turnover duration reduced from 8.44 days to 5.03 days following introduction of the cold chain positioning system,and the percentage of timely sample delivery increased from 31.69%to 77.90%,while the withdrawal rate of unqualified samples reduced from 0.12%to 0.08%.The cold chain positioning system meets the requirements of transport of filter paper-dried blood spot samples,which has a high potential in screening of neonatal inherited metabolic diseases.

关 键 词：新生儿疾病筛查 样本运输 定位系统 

分 类 号：R722.11[医药卫生—儿科]