Nanotechnological strategies for prostate cancer imaging and diagnosis  

作　　者：Thecla Trinity Wheeler Pei Cao Muhammad Daniyal Ghouri Tianjiao Ji Guangjun Nie Yuliang Zhao 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology,Beijing 100190,China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science China Chemistry》2022年第8期1498-1514,共17页中国科学（化学英文版）

基　　金：supported by the National Key R&D Program of China(2021YFA0909900)。

摘　　要：The high incidence rates and complicated subtypes of prostate cancer(PCa)call for the demand of the precise diagnostic and therapeutic strategies.Current clinical imaging techniques,such as MRI,CT,and ultrasonography are difficult to accurately detect the early-stage tumor lesions,and biochemical assays or biopsies are invasive and cannot provide sufficient information for the PCa staging and classification.Nanotechnology has the potential to improve the accuracy of current diagnosis strategies by targeting specific PCa biomarkers and/or integrating multiple imaging modes.In this review,we briefly introduce current clinical PCa imaging strategies and their major limitations,and highlight representative works on nanoparticle-mediated multimode imaging strategies.We also discuss the challenges of nanotechnology-based PCa diagnosis,and come up with suggestions and perspectives.

关 键 词：prostate cancer DIAGNOSIS NANOTECHNOLOGY TARGETING multi-mode imaging 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R737.25[医药卫生—肿瘤]