儿童抽动障碍相关基因的研究进展  

Advance in tic disorder related genes in children

作　　者：柴莹莹(综述) 林文鑫 郑帼[1] 黄艳军(审校)[1] Chai Yingying;Lin Wenxin;Zheng Guo;Huang Yanjun(Department of Neurology,Children's Hospital of Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]南京医科大学附属儿童医院神经内科,210000

出　　处：《国际儿科学杂志》2022年第6期389-392,共4页International Journal of Pediatrics

摘　　要：抽动障碍(tic disorders,TD)多发病于2岁至15岁的儿童,以快速、不自主、非节律性、单一或多部位肌肉运动或发声抽动为特点的一种复杂的慢性神经精神障碍。TD临床表现多样,通常与各种精神病理或行为共病有关,包括注意缺陷多动障碍、焦虑、抑郁和强迫症等。TD的病因及发病机制仍不完全明确,免疫、遗传、神经生化及环境等因素是目前比较公认的与TD发病有关的因素。近年来有关TD与遗传因素的研究逐渐增多,但至今对TD的致病基因尚无明确结论,该文对目前发现的与TD相关的致病候选基因进行论述。Tic disorders(TD),a complex chronic neuropsychiatric disorder characterized by rapid,involuntary,non rhythmic,single or multiple muscle movements or vocal twitches,usually occurs in children aged from 2 to 15 years.TD has various clinical manifestations,which are usually related to various psychopathology or behavioral comorbidities,including attention deficit hyperactivity disorder,anxiety,depression and obsessive-compulsive disorder.The etiology and pathogenesis of TD are still not completely clear.Immune,genetic,neurobiochemical and environmental factors are generally recognized as factors related to the pathogenesis of TD.In recent years,the research on TD and genetic factors has gradually increased,but so far there is no clear conclusion on the pathogenic genes of TD.This paper only discusses the genes related to TD.

关 键 词：抽动障碍 遗传 基因 

分 类 号：R749.94[医药卫生—神经病学与精神病学]