Deuterated N-difluoromethylthiophthalimide:A stable,scalable reagent for radical and electrophilic deuteriodifluoromethylthiolations  

作　　者：Chunyang Hu Fangming Chen Guo-Ping Lu Wen-Bin Yi 

机构地区：[1]School of Chemistry and Chemical Engineering,Nanjing University of Science and Technology,Nanjing 210094,China [2]Key Laboratory of Organofluorine Chemistry,Shanghai Institute Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Chemical Letters》2022年第9期4293-4297,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (Nos. 21776138, 22078161);the Fundamental Research Funds for the Central Universities (Nos. 30920021124, 30918011314);the Natural Science Foundation of Jiangsu Province (No. BK20180476);the Postdoctoral Science Foundation Funded Project (No. 2019M661848);the Priority Academic Program Development of Jiangsu Higher Education Institutions;the Center for Advanced Materials and Technology in Nanjing University of Science and Technology for their financial support

摘　　要：A new,stable and scalable reagent for deuteriodifluoromethylthiolation(deuterated N-difluoromethylthiophthalimide,PhthSCF_(2)D)has been developed.This reagent can be applied for the photocatalytic radical deuteriodifluoromethylthiolation of various olefins and aldehydes(30 examples).Meanwhile,it can achieve the electrophilic deuteriodifluoromethylthiolation of a series of electrophilic substrates including electron-rich arenes,aryl/vinylboronicacids,alkynes,amines,thiols andβ-ketoesters(22 examples).Some complex molecules can also be applied in both radical and electrophilic deuteriodifluoromethylthiolation using PhthSCF_(2)D as the reagent.

关 键 词：DEUTERATION Deuteriodifluoromethylthiolation PHOTOCATALYTIC ELECTROPHILIC RADICAL 

分 类 号：TQ246.31[化学工程—有机化工]