急性胰腺炎致Wernicke-Korsakoff综合征伴乳头体萎缩1例  

One case report of Wernicke-Korsakoff syndrome with corpora candicans atrophy resulting from acute pancreatitis

作　　者：郭卫娜 康宁 李晓莎 李玲[2] 高俊淑[2] 李娜[2] 王天俊[2] Guo Weina;Kang Ning;Li Xiaosha;Li Ling;Gao Junshu;Li Na;Wang Tianjun(Department of Neurology,Baoding No.1 Central Hospital,Baoding 071000,China;Department of Neurology,Hebei General Hospital,Shijiazhuang 050000,China)

机构地区：[1]保定市第一中心医院神经内科,河北保定071000 [2]河北省人民医院神经内科,河北石家庄050000

出　　处：《临床荟萃》2022年第7期644-647,共4页Clinical Focus

摘　　要：目的探讨Wernicke-Korsakoff综合征(WKS)的病因、临床表现、影像学特征及治疗方法。方法回顾性分析1例急性胰腺炎致WKS伴乳头体萎缩病例,并复习相关文献。结果患者女性,29岁,妊娠期间突发急性胰腺炎致剖宫产,经过长期禁食水、胃肠减压、血浆置换等治疗后逐渐出现Wernicke’s脑病(Wernicke’s encephalopathy,WE)典型三联征表现,后期出现虚构、妄想及顺行性遗忘,头颅MR提示双侧丘脑近脑室对称性异常信号且乳头体逐渐萎缩,综上诊断为WKS,予以维生素B1治疗后恢复良好。结论WKS是一种可治疗、可预防的疾病。对需较长时间禁食的患者,临床医生都应警惕该病的发生,注意补充维生素B1,避免造成不良后果。Objective To explore the etiology,clinical features,imaging characteristics and therapeutic regimen for Wernicke-Korsakoff syndrome(WKS).Methods One case of WKS associated with corpora candicans atrophy resulting from acute pancreatitis was retrospective analyzed,and related literature were reviewed.Results A 29-yearold female patient suffered from sudden acute pancreatitis during pregnancy,and was subject to cesarean section.Typical Wernicke's encephalopathy(WE)triad-sign manifestations were gradually found with the patient treated with long-term fasting&water deprivation,gastrointestinal decompressionand plasma exchange,the fabrication,delusion,anterograde forgetting and head nuclear magnetic were found with the patient later,symmetry abnormal signal of bilateral thalamus near ventricle and atrophic corpora candicans appeared gradual.The patient was comprehensively diagnosed as WKS and recovered well after vitamin B1 treatment.Conclusion WKS is a treatable and preventable disease.Clinicians should be alert to the occurrence of the disease for patients required to have fasting for a long time,and must supplement B1 to avoid adverse consequences.

关 键 词：急性胰腺炎 硫胺素 WERNICKE-KORSAKOFF综合征 乳头体萎缩 

分 类 号：R576[医药卫生—消化系统]