Infections in Alcoholic Hepatitis  

作　　者：Bhupinder Kaur Russell Rosenblatt Vinay Sundaram 

机构地区：[1]Internal Medicine Department,Cedars-Sinai Medical Center,Los Angeles,CA,USA [2]Department of Gastroenterology and Hepatology,Weill Cornell Medicine,New York,NY,USA [3]Department of Gastroenterology and Hepatology and Comprehen-sive Transplant Center,Cedars-Sinai Medical Center,Los Angeles,CA,USA

出　　处：《Journal of Clinical and Translational Hepatology》2022年第4期718-725,共8页临床与转化肝病杂志（英文版）

摘　　要：Severe alcoholic hepatitis (sAH) is defined by a modified discriminant function ≥32 or model for end-stage liver disease (MELD) >20. Patients with sAH are in an immu-nocompromised state attributed to cirrhosis-related immu-noparesis and corticosteroid use. Individuals with sAH often develop severe infections that adversely impact short-term prognosis. Currently, the corticosteroid prednisolone is the only treatment with proven efficacy in sAH;however, the combination of corticosteroid treatment and altered host defense in sAH has been thought to increase the risk of acquiring of bacterial, opportunistic fungal, and viral infec-tions. Newer studies have shown that corticosteroids do not increase occurrence of infections in those with sAH;unfor-tunately, the lack of response to corticosteroids may instead predispose to infection development. Prompt and appropri-ate antibiotic treatment is therefore essential to improving patient outcomes. This review highlights common infections and risk factors in patients with sAH. Additionally, current diagnostic, therapeutic, and prophylactic strategies in these patients are discussed.

关 键 词：Alcoholic hepatitis INFECTIONS CORTICOSTEROIDS STOPAH Antibiotic treatment ASPERGILLOSIS IMMUNODEFICIENCY Alcoholic liver disease 

分 类 号：R575.1[医药卫生—消化系统]