茶黄素类天然产物抗肿瘤机制的研究进展  

Research Progress on Anti-Tumor Mechanism of Theaflavins Natural Products

作　　者：张雪 尹君丽 王稼祥 石文贵 焦作义[1,2] ZHANG Xue;YIN Junli;WANG Jiaxiang;SHI Wengui;JIAO Zuoyi(Department of General Surgery,Second Hospital of Lanzhou University,Lanzhou 730030,China;Cuiying Biomedical Research Center,Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院普外科,兰州730030 [2]兰州大学第二医院萃英生物医学研究中心,兰州730030

出　　处：《肿瘤防治研究》2022年第8期820-826,共7页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(82160487);兰州大学第二医院萃英学子科研培育计划(CYXZ2020-37)。

摘　　要：茶黄素类(Theaflavins)是从红茶或绿茶中提取的一类天然产物,在胃癌、肝癌及乳腺癌等多种肿瘤中具有显著的抗肿瘤效果,一度被认为是癌症新药研发的新方向。但是茶黄素抗肿瘤的机制涉及多种生物学过程,且调控复杂。因此,本文就茶黄素在促进肿瘤细胞凋亡、诱导肿瘤细胞有丝分裂阻滞和调节肿瘤免疫过程中的作用展开综述,并概述了茶黄素通过MAPK、PI3K/AKT、Hedgehog、NF-κB、JAK/STAT及Wnt/β-Catenin等信号通路抑制肿瘤发生和生长的机制,以期为癌症治疗及抗癌药物研发提供新的思路。Theaflavins are a class of natural products extracted from black tea or green tea,with significant anti-tumor effects on gastric cancer,liver cancer,breast cancer and other tumors.Theaflavins were once considered as the new products for anticancer therapy.However,the anti-tumor mechanism of theaflavins involves a variety of biological processes,and the regulation is complex.Therefore,this article summarizes the role of theaflavins in promoting tumor cell apoptosis,inducing tumor cell mitotic arrest and regulating tumor immunity,and reviews the inhibition of tumorigenesis and growth through MAPK,PI3K/AKT,Hedgehog,NF-κB,JAK/STAT and Wnt/β-Catenin signal pathways,in order to provide new ideas for cancer treatment and anti-cancer drug development.

关 键 词：茶黄素类 信号通路 抗肿瘤 作用机制 

分 类 号：R730[医药卫生—肿瘤]