食源性肠道疾病的微生态防治进展  

Progress in the prevention of food-borne intestinal diseases

作　　者：李一娟 邵开生 陶雪莹[1] 何丽华[2] 魏华[1,2] 张志鸿[1,2] LI Yi-juan;SHAO Kai-sheng;TAO Xue-ying;HE Li-hua;WEI Hua;ZHANG Zhi-hong(State Key Laboratory of Food Science and Technology,Nanchang University,Nanchang,Jiangri 330047,China;不详)

机构地区：[1]南昌大学食品科学与技术国家重点实验室,江西南昌330047 [2]南昌大学中德联合研究院

出　　处：《中国微生态学杂志》2022年第7期846-850,共5页Chinese Journal of Microecology

基　　金：国家自然科学基金青年科学基金(32101915);江西省自然科学基金(20212BAB215033)。

摘　　要：肠道是一个复杂的微生态系统,其中存在着数以万亿计的微生物以及丰富的营养物质,微生物群依赖肠道营养物质生长并经长期的进化适应而特异性地存在于宿主肠道,通过其代谢活动及其产物维持宿主的微生态稳态。肠道微生物可抵抗外来病原微生物的入侵和定植,预防肠道疾病的发生,其作用机制包括竞争营养物质和生态位、产生拮抗细菌素、干扰群体感应和免疫介导等。饮食和药物等外界因素与遗传因素均可改变宿主的肠道环境,从而影响机体对入侵病原微生物的抵抗。本文就肠道食源性疾病的微生态防治研究进行综述,为预防和治疗肠道感染性疾病提供参考。The intestine is a complex microbe ecosystem which is rich in microbiota and nutrients. The microbiota inhabit in the gut with these nutrients and adapt to the host specifically. They maintain the balance by metabolic activities and their products. Gut microbiota exert the ability against pathogen invasion and colonization, and prevent intestinal diseases. The mechanisms include competition for nutrients and niche, production of antagonistic bacteriocins, interference with quorum sensing, and immune mediation. Diet, drugs and other external factors as well as genetic factors change the intestinal environment of the host, and affect the resistance to invading pathogens. In this review, the prevention strategies of food-borne intestinal diseases were summarized to provide reference for the prevention and treatment of various intestinal infectious diseases.

关 键 词：微生态系统 肠道微生物 病原微生物 肠道疾病 膳食 

分 类 号：R378[医药卫生—病原生物学]