化妆品中三种致敏香料GC-MS检测方法的研究与建立  

Study and Establishment of GC-MS Detection Method for Three Kinds of Sensitizing Spices in Cosmetics

作　　者：李杰 吉伟佳 杨婷婷 易路遥 LI Jie;JI Weijia;YANG Tingting;YI Luyao(Jiangxi Institute For Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine,Jiangxi Province Engineering Research Center of Drug and Medical Device Quality,Nanchang Jiangxi 330029,China)

机构地区：[1]江西省药品检验检测研究院,国家药品监督管理局中成药质量评价重点实验室,江西省药品与医疗器械质量工程技术研究中心,江西南昌330029

出　　处：《药品评价》2022年第12期716-720,共5页Drug Evaluation

基　　金：江西省药品监督管理局科技计划[2019JS03];江西省药品监督管理局科技计划[2019JS40]。

摘　　要：目的:建立了气相色谱-串联质谱(GC-MS)测定化妆品中致敏香料新铃兰醛Ⅰ、新铃兰醛Ⅱ、苔黑醛和氯化苔黑醛含量的方法。方法:采用通过式SPE净化柱对霜剂、乳剂、粉剂和液体类化妆品进行样品处理,GC-MS定性定量测定。结果:新铃兰醛Ⅰ、新铃兰醛Ⅱ、苔黑醛和氯化苔黑醛线性关系良好,相关系数(r)>0.990,各种化妆品基质的回收率在72.3%~125.4%,RSD<10%,方法定量限(LOQ)为新铃兰醛Ⅰ3.6 mg/kg、新铃兰醛Ⅱ1.4 mg/kg、苔黑醛1.9 mg/kg和氯化苔黑醛5.0mg/kg。结论:该分析方法前处理简单,高效准确,选择性好,可用于化妆品中致敏香料含量的测定分析。Objective:To establish a method for the determination of the content of sensitizing spice lyral I,lyralⅡ and atranol and chloroatranol in cosmetics by GC-MS.Methods:The cream,emulsion,powder and liquid water-based cosmetics were pretreated by a pass-through SPE purification column.Then the GC-MS was used to make a qualitative and quantitative determination.Results:The lyral I,lyralⅡ,atranol and chloroatranol had good linearity in certain ranges,the correlation coefficients (r) was greater than 0.990.The recovery rate of various cosmetic substrate materials was between 72.3% and 125.4%,and the RSD was less than 10%.The LOQ of lyral I was 3.6 mg/kg,the LOQ of lyralⅡ was 1.4 mg/kg,the LOQ of atranol was 1.9 mg/kg,andthe LOQ of chloroatranol was 5.0 mg/kg.Conclusion:This method is preprocessing simple,efficient,accurate and selective.It can be used for the determination and analysis of allergenic spice content in cosmetics.

关 键 词：化妆品 香料 新铃兰醛 苔黑醛 氯化苔黑醛 气相色谱-串联质谱 

分 类 号：O657.63[理学—分析化学] TQ658[理学—化学]