Treatment of gastric carcinoma with lymphoid stroma by immunotherapy:A case report  

作　　者：Yu-Jie Cui Yan-Yan Ren Hong-Zhen Zhang 

机构地区：[1]Department of Oncology,Hebei General Hospital,Shijiazhuang 050051,Hebei Province,China [2]Department of Medicine,Hebei North University,Zhangjiakou 075000,Hebei Province,China

出　　处：《World Journal of Clinical Cases》2022年第25期8962-8967,共6页世界临床病例杂志

基　　金：Supported by the Key R&D Program of Hebei Province,Health Care and Biomedicine,No.18277718D(to Cui YJ)。

摘　　要：BACKGROUND Gastric cancer with lymphoid stroma(GCLS)is a rare type of gastric cancer characterized by abundant lymphocytic infiltration of the stroma.It is an EpsteinBarr virus-associated gastric cancer with a better prognosis than typical gastric cancer but with similar symptoms.GCLS diagnosis is based on pathological,histological and immunohistochemical examination and there are no standardized guidelines for treatment.CASE SUMMARY This case report describes a 72-year-old man with a 6-mo history of abdominal pain.Endoscopy revealed ulcerative lesions in the stomach and gastric cancer was suspected.A preoperative endoscopic biopsy indicated undifferentiated carcinoma and postoperative pathological,histological and immunohistochemical analyses of the resected specimen confirmed a final diagnosis of GCLS.CONCLUSION The patient showed high programmed cell death-ligand 1 expression and recovered well after immunotherapy.

关 键 词：Lymphoid stroma Gastric cancer Epstein-Barr virus Programmed cell death-ligand 1 IMMUNOTHERAPY Prognosis Case report 

分 类 号：R735.2[医药卫生—肿瘤]